TUMORIGENIC CONVERSION OF PRIMARY EMBRYO FIBROBLASTS REQUIRES AT LEAST 2 COOPERATING ONCOGENES
TUMORIGENIC CONVERSION OF PRIMARY EMBRYO FIBROBLASTS REQUIRES AT LEAST 2 COOPERATING ONCOGENES
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DOI：
10.1038/304596a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
WEINBERG, RA
中科院分区：
文献类型：
--
作者：
LAND, H;PARADA, LF;WEINBERG, RA
人ras癌基因转染胚胎成纤维细胞不会将其转化为肿瘤细胞，除非成纤维细胞在转染前已建立并永生化。如果第二致癌基因如病毒或细胞myc基因或多瘤大T抗原基因与ras基因一起导入，胚胎成纤维细胞成为致瘤性的。
Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumor cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a 2nd oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.