Association Between p53 codon 72 Genetic Polymorphism and Tobacco Use and Lung Cancer Risk
Association Between p53 codon 72 Genetic Polymorphism and Tobacco Use and Lung Cancer Risk
复制标题
DOI：
10.1007/s00408-008-9133-3
复制
发表时间：
2009-04-01
期刊：
影响因子：
5
通讯作者：
Irarrazabal, Carlos E.
中科院分区：
文献类型：
--
作者：
Caceres, Dante D.;Quinones, Luis A.;Irarrazabal, Carlos E.
肺癌（LCa）是男性癌症死亡的主要原因。遗传和环境因素在其病因学中起协同作用。我们在111例肺癌病例和133例非癌对照中，采用两种病例对照设计，探讨了p53 cd 72多态性与吸烟之间的基因-环境交互作用（G x E）及其对LCa风险的影响。我们使用调整后的无条件logistic模型评估了相互作用比值比（IOR）。我们发现，在病例对照和仅病例设计中，Pro* 等位基因携带者与吸烟习惯之间存在显著的正交互作用：IOR分别为3.90（95%置信区间[CI] = 1.10-13.81）和3.05（95% CI = 1.63-5.72）。这些探索性的结果表明，吸烟习惯和Pro等位基因的易感性对肺癌风险的协同效应相比，单独的每个危险因素。
Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G x E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR) using an adjusted unconditional logistic model. We found a significant and positive interaction association between Pro* allele carriers and smoking habits in both case-control and case-only designs: IOR = 3.90 (95% confidence interval [CI] = 1.10-13.81) and 3.05 (95% CI = 1.63-5.72), respectively. These exploratory results suggest a synergistic effect of the smoking habit and the susceptibility of the Pro allele on lung cancer risk compared with each risk factor alone.