Tetrodotoxin blocks the formation of ocular dominance columns in goldfish.
Tetrodotoxin blocks the formation of ocular dominance columns in goldfish.
复制标题
河豚毒素可阻止金鱼眼优势柱的形成。
作者：
R. Meyer
金鱼双眼的光学纤维可以同时在一个顶盖上再生。不同时间的放射自显影显示再生的左右纤维广泛重叠长达4周，随后在8周时分离成眼优势柱。连续使用河豚毒素治疗双眼可防止眼球形成长达13周，如果在6周时开始治疗，效果相同。当11周后停止河豚毒素治疗时，在接下来的3周内形成柱状。仅阻断一只眼在8周时确实阻止了柱的形成。
Optic fibers from both eyes were made to regenerate simultaneously into one tectum in goldfish. Autoradiography at various times later revealed that regenerating left and right fibers overlapped extensively for up to 4 weeks and subsequently segregated into eye dominance columns by 8 weeks. Continuous tetrodotoxin treatment of both eyes prevented the formation of columns for up to 13 weeks and was equally effective if begun at 6 weeks. When tetrodotoxin treatment was stopped after 11 weeks, columns subsequently formed in the next 3 weeks. Blockade of only one eye did prevent column formation at 8 weeks.