Diabetic cardiomyopathy, causes and effects.

Diabetic cardiomyopathy, causes and effects.
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DOI:
10.1007/s11154-010-9131-7
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发表时间:
2010-03
影响因子:
8.2
通讯作者:
Abel, Evan Dale
Abel, Evan Dale
中科院分区:
医学2区
文献类型:
--
作者:
Boudina, Sihem;Abel, Evan Dale

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即使在控制冠状动脉疾病和高血压后,糖尿病仍与心力衰竭的发生率增加有关。因此,随着糖尿病性心肌病越来越被临床医生所认可,更好地了解其病理生理学对于糖尿病相关心血管功能障碍的早期诊断和治疗策略的制定是必要的。本文将对近年来糖尿病性心肌病的临床和基础研究进行综述。讨论将集中在糖尿病心肌发生的结构、功能和代谢变化,以及这些变化如何在受影响的人和相关动物模型中促进糖尿病性心肌病的发展。
Diabetes is associated with increased incidence of heart failure even after controlling for coronary artery disease and hypertension. Thus, as diabetic cardiomyopathy has become an increasingly recognized entity among clinicians, a better understanding of its pathophysiology is necessary for early diagnosis and the development of treatment strategies for diabetes-associated cardiovascular dysfunction. We will review recent basic and clinical research into the manifestations and the pathophysiological mechanisms of diabetic cardiomyopathy. The discussion will be focused on the structural, functional and metabolic changes that occur in the myocardium in diabetes and how these changes may contribute to the development of diabetic cardiomyopathy in affected humans and relevant animal models.
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