The nonelectrolyte permeability of planar lipid bilayer membranes.
The nonelectrolyte permeability of planar lipid bilayer membranes.
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DOI：
10.1085/jgp.75.4.427
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发表时间：
1980-04
期刊：
影响因子：
--
通讯作者：
Finkelstein A
中科院分区：
文献类型：
--
作者：
Orbach E;Finkelstein A
卵磷脂双层膜对非电解质的渗透性与奥弗顿规则基本一致。式中为Pd α DKhc，其中/Pd为溶质通过双分子层的渗透系数，Khc为溶质的烃水分配系数，D为溶质在整体烃中的扩散系数。到目前为止，分区系数是渗透率系数相对大小的主要决定因素；扩散系数只起很小的作用。我们注意到，最近强调理论计算的膜内扩散系数（Dm'S）已经转移了对实验可测量和生理相关渗透系数（Pd'S）的关注，并且模糊了奥弗顿规则的简单性和实用性。
The permeability of lecithin bilayer membranes to nonelectrolytes is in reasonable agreement with Overton's rule. The is, Pd alpha DKhc, where/Pd is the permeability coefficient of a solute through the bilayer, Khc is its hydrocarbon:water partition coefficient, and D is its diffusion coefficient in bulk hydrocarbon. The partition coefficients are by far the major determinants of the relative magnitudes of the permeability coefficients; the diffusion coefficients make only a minor contribution. We note that the recent emphasis on theoretically calculated intramembranous diffusion coefficients (Dm'S) has diverted attention from the experimentally measurable and physiologically relevant permeability coefficients (Pd'S) and has obscured the simplicity and usefulness of Overton's rule.