Dietary phosphorus and blood pressure - International Study of Macro- and Micro-Nutrients and Blood Pressure
Dietary phosphorus and blood pressure - International Study of Macro- and Micro-Nutrients and Blood Pressure
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DOI：
10.1161/hypertensionaha.107.103747
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发表时间：
2008-03-01
期刊：
影响因子：
8.3
通讯作者：
Stamler, Jeremiah
中科院分区：
文献类型：
--
作者：
Elliott, Paul;Kesteloot, Hugo;Stamler, Jeremiah
血压升高是全世界发病率和死亡率的主要原因；需要改进全人群预防的营养方法。关于膳食磷和血压的数据很少，也没有关于磷、镁和钙对血压可能的联合影响的数据。宏观和微量营养素与血压的国际研究是一项横断面流行病学研究，对象为日本、中国、英国和美国的17个人口样本中的4,680名年龄在40至59岁的男性和女性。4次就诊时测量血压8次。膳食摄入量来自四次24小时召回以及有关补充剂使用的数据。在一系列预先定义的多元回归模型中，饮食磷与血压呈负相关，并相继增加了潜在的混杂因素，包括非饮食因素和饮食因素。对于2238名“非干预”个体，即那些没有特殊饮食/营养补充剂或诊断/治疗心血管疾病或糖尿病的人，每高232毫克/1000千卡(2SD)高饮食磷的估计血压差分别为-1.1至-2.3毫米汞收缩压/-0.6至-1.5毫米汞舒张压(n=4680)和-1.6至-3.5毫米汞收缩压/-0.8至-1.8毫米汞舒张压。膳食钙、镁与磷呈正相关(偏r=0.71和r=0.68)，与血压呈负相关。摄入量高于上述3种矿物质的人群，血压降低1.9至4.2毫米汞/1.2至2.4毫米汞舒张压，而低于特定国家的中位数。这些结果表明，增加磷/矿物质摄入量可能会降低血压，这是预防和控制高血压前期和高血压的更健康饮食模式的建议的一部分。
Raised blood pressure is a leading cause of morbidity and mortality worldwide; improved nutritional approaches to population-wide prevention are required. Few data are available on dietary phosphorus and blood pressure and none are available on possible combined effects of phosphorus, magnesium, and calcium on blood pressure. The International Study of Macro- and Micro-Nutrients and Blood Pressure is a cross-sectional epidemiologic study of 4680 men and women ages 40 to 59 from 17 population samples in Japan, China, United Kingdom, and United States. Blood pressure was measured 8 times at 4 visits. Dietary intakes were obtained from four 24-hour recalls plus data on supplement use. Dietary phosphorus was inversely associated with blood pressure in a series of predefined multiple regression models, with the successive addition of potential confounders, both nondietary and dietary. Estimated blood pressure differences per 232 mg/1000 kcal (2 SD) of higher dietary phosphorus were -1.1 to -2.3 mm Hg systolic/-0.6 to -1.5 mm Hg diastolic (n = 4680) and -1.6 to -3.5 mm Hg systolic/-0.8 to -1.8 mm Hg diastolic for 2238 "nonintervened" individuals, ie, those without special diet/nutritional supplements or diagnosis/treatment for cardiovascular disease or diabetes. Dietary calcium and magnesium, correlated with phosphorus (partial r = 0.71 and r = 0.68), were inversely associated with blood pressure. Blood pressures were lower by 1.9 to 4.2 mm Hg systolic/1.2 to 2.4 mm Hg diastolic for people with intakes above versus below country-specific medians for all 3 of the minerals. These results indicate the potential for increased phosphorus/mineral intake to lower blood pressure as part of the recommendations for healthier eating patterns for the prevention and control of prehypertension and hypertension.