Anti-obese effects of two Lactobacilli and two Bifidobacteria on ICR mice fed on a high fat diet
Anti-obese effects of two Lactobacilli and two Bifidobacteria on ICR mice fed on a high fat diet
复制标题
DOI：
10.1016/j.bbrc.2016.10.031
复制
发表时间：
2016-11-11
影响因子：
3.1
通讯作者：
Ji, Geun Eog
中科院分区：
文献类型：
--
作者：
Li, Zhipeng;Jin, Hui;Ji, Geun Eog
以前的研究人员已经证明，益生菌可以对高脂肪饮食（HFD）喂养的小鼠具有抗肥胖作用，并改善代谢综合征。益生菌的有益效果被认为是菌株依赖性的。在本研究中，将两种候选乳杆菌菌株，干酪乳杆菌IBS041、嗜酸乳杆菌AD031和两种双歧杆菌菌株，两歧双歧杆菌BGN 4和长双歧杆菌BORI，分别给予HFD喂养的小鼠8周。B。LONGUM BORI显著抑制小鼠体重增加而不影响食物摄入。L.嗜酸乳杆菌和B.两歧双歧杆菌BGN 4显著降低小鼠肝脏中的甘油三酯水平，而B. LONGUM BORI显著降低肝脏总胆固醇水平。嗜酸乳杆菌和B.双歧杆菌BGN 4显著抑制血清中天冬氨酸转氨酶和丙氨酸转氨酶的活性。膳食补充L.嗜酸乳杆菌B.双歧杆菌BGN 4和B。长梗茯苓能有效改善肝细胞水肿变性和脂肪变性。在四种益生菌候选物中，益生菌B. longum BORI和B. bifidum BGN 4和L.嗜酸乳杆菌AD 031具有良好的减肥效果，并抑制肝脏中的脂质沉积。(C)2016由Elsevier Inc.出版
Previous researchers have documented that probiotic bacteria can have anti-obesity effects on mice fed a high fat diet (HFD) and improve metabolic syndrome. The beneficial effects of the probiotic bacteria are suggested to be strain dependent. In this study, two candidate lactobacteria strains, Lactobacillus casei IBS041, Lactobacillus acidophilus AD031 and two bifidobacteria strains, Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI, were individually administered to HFD-fed mice for 8 weeks. B. longum BORI significantly suppressed mouse weight gain without affecting food intake. L. acidophilus and B. bifidum BGN4 significantly decreased triglyceride levels in mouse liver while B. longum BORI significantly lowered total cholesterol levels in liver. L acidophilus and B. bifidum BGN4 significantly inhibited serum activities of aspartate transaminase and alanine transaminase. Diet supplementation with L. acidophilus, B. bifidum BGN4 and B. longum BORI efficiently improved hepatocyte hydropic degeneration and hepatic steatosis. Of the four probiotic candidates, the bifidobacteria B. longum BORI and B. bifidum BGN4, developed in our laboratory, and L. acidophilus AD031showed excellent anti-obesity effects and suppressed lipid deposition in liver. (C) 2016 Published by Elsevier Inc.