Nephrocalcinosis in Sjögren's syndrome: a late sequela of renal tubular acidosis
Nephrocalcinosis in Sjögren's syndrome: a late sequela of renal tubular acidosis
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干燥综合征中的肾钙质沉着症：肾小管性酸中毒的晚期后遗症
DOI：
10.1111/j.1365-2796.1991.tb00429.x
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发表时间：
1991
影响因子：
11.1
通讯作者：
P. Youinou
中科院分区：
文献类型：
--
作者：
H. Moutsopoulos;J. Clèdes;F. Skopouli;M. Elisaf;P. Youinou
抽象的。干燥综合征（SS）是一种自身免疫性外分泌病，25%的患者发展为全身性自身免疫性疾病，导致全身并发症，其中之一是肾脏受累。它主要表现为间质性肾炎，表现为低尿症、远端肾小管酸中毒（RTA）和尿崩症。我们在此描述了5例1型RTA（高氯血症性代谢性酸中毒伴阴离子间隙和碱性尿pH）的SS患者，他们发生了肾结石、肾钙质沉着症和肾功能不全。酸中毒引起的高钙尿是4例患者的主要肾钙质沉着倾向因素; 4例受试者显示肾浓缩能力降低，2例出现低钾血症。
Abstract. Sjögren's syndrome (SS) is an autoimmune exocrinopathy that develops into systemic autoimmune disease in 25% of patients, leading to general complications, one of which is kidney involvement. It presents mainly as interstitial nephritis, disclosed by hyposthenuria, distal renal tubular acidosis (RTA) and diabetes insipidus. We here describe five cases of SS with type‐1 RTA (hyperchloraemic metabolic acidosis with an anion gap and alkaline urine pH) who developed nephrolithiasis, nephrocalcinosis and renal insufficiency. Hypercalciuria due to acidosis was the main nephrocalcinosis‐prone factor in four patients; four subjects displayed diminished renal concentrating capacity, and two had hypokalaemia.