Emerging stem cell therapies: treatment, safety, and biology.
Emerging stem cell therapies: treatment, safety, and biology.
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DOI：
10.1155/2012/521343
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发表时间：
2012
影响因子：
4.3
通讯作者：
Lufkin T
中科院分区：
文献类型：
--
作者：
Sng J;Lufkin T
干细胞是生命的基本组成部分，有助于所有高等生物的发生和发展。成体干细胞的发现引发了治疗和再生医学的一场持续革命，并提出了针对先前晚期疾病的新疗法。造血干细胞移植是干细胞治疗成功的第一个例子，被广泛用于治疗各种疾病，包括成人t细胞白血病淋巴瘤和多发性骨髓瘤。间充质干细胞的自体移植越来越多地用于催化间充质组织和其他组织的修复，包括肺和心脏，并用于治疗各种疾病，如中风、多发性硬化症和糖尿病。其他成体干细胞如神经干细胞、乳腺干细胞、肠道干细胞、内耳干细胞和睾丸干细胞的治疗潜力也越来越受到关注。诱导多能干细胞的发现使我们对多能性和癌变的潜在表观遗传关键有了更好的了解。对这些表观遗传差异及其影响的生理变化进行更深入的研究，将有助于设计更安全、更有针对性的治疗方法。
Stem cells are the fundamental building blocks of life and contribute to the genesis and development of all higher organisms. The discovery of adult stem cells has led to an ongoing revolution of therapeutic and regenerative medicine and the proposal of novel therapies for previously terminal conditions. Hematopoietic stem cell transplantation was the first example of a successful stem cell therapy and is widely utilized for treating various diseases including adult T-cell leukemia-lymphoma and multiple myeloma. The autologous transplantation of mesenchymal stem cells is increasingly employed to catalyze the repair of mesenchymal tissue and others, including the lung and heart, and utilized in treating various conditions such as stroke, multiple sclerosis, and diabetes. There is also increasing interest in the therapeutic potential of other adult stem cells such as neural, mammary, intestinal, inner ear, and testicular stem cells. The discovery of induced pluripotent stem cells has led to an improved understanding of the underlying epigenetic keys of pluripotency and carcinogenesis. More in-depth studies of these epigenetic differences and the physiological changes that they effect will lead to the design of safer and more targeted therapies.
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影响因子：
48
作者：
Connick, Peter;Kolappan, Madhan;Crawley, Charles;Webber, Daniel J.;Patani, Rickie;Michell, Andrew W.;Du, Ming-Qing;Luan, Shi-Lu;Altmann, Daniel R.;Thompson, Alan J.;Compston, Alastair;Scott, Michael A.;Miller, David H.;Chandran, Siddharthan
通讯作者：
Chandran, Siddharthan
影响因子：
4
作者：
Bae, Daekyeong;Mondragon-Teran, Paul;Veraitch, Farlan S.
通讯作者：
Veraitch, Farlan S.
影响因子：
2.8
作者：
Breuskin, Ingrid;Bodson, Morgan;Malgrange, Brigitte
通讯作者：
Malgrange, Brigitte
影响因子：
3.7
作者：
Aharonowiz M;Einstein O;Fainstein N;Lassmann H;Reubinoff B;Ben-Hur T
通讯作者：
Ben-Hur T
影响因子：
11.2
作者：
Bernardo, Maria Ester;Zaffaroni, Nadia;Locatelli, Franco
通讯作者：
Locatelli, Franco