Bitter Melon: Antagonist to Cancer
Bitter Melon: Antagonist to Cancer
复制标题
DOI：
10.1007/s11095-010-0057-2
复制
发表时间：
2010-06-01
影响因子：
3.7
通讯作者：
Ray, Ratna B.
中科院分区：
文献类型：
--
作者：
Nerurkar, Pratibha;Ray, Ratna B.
尽管在抗癌疗法的开发方面取得了实质性进展，但癌症的发病率在世界范围内仍在增加。控制癌症的一种方法可能是通过饮食进行预防，从而抑制一种或多种肿瘤事件并降低癌症风险。膳食化合物通过调节细胞内稳态和细胞死亡机制来抑制致癌过程，从而在对抗癌症方面提供了巨大的潜力。几个世纪以来，阿育吠陀（印度传统医学）一直推荐使用苦瓜（Momorea charantia）作为预防和治疗糖尿病及其相关并发症的功能性食物。值得一提的是，苦瓜提取物对动物和人类都没有副作用。苦瓜的抗肿瘤活性最近开始显现。本文综述了苦瓜及其活性成分在癌症化学预防和抗癌方面的研究进展。几组研究人员报告说，在许多癌细胞系中治疗甜瓜相关产品可诱导细胞周期停滞和凋亡，而不影响正常细胞生长。因此，苦瓜的效果应该对健康有益，并且使用未改性的膳食产品具有成本效益。
The incidence of cancer is increasing worldwide, in spite of substantial progress in the development of anti-cancer therapies. One approach to control cancer could be its prevention by diet, which inhibits one or more neoplastic events and reduces cancer risk. Dietary compounds offer great potential in the fight against cancer by inhibiting the carcinogenesis process through the regulation of cell homeostasis and cell-death machineries. For centuries, Ayurveda (Indian traditional medicine) has recommended the use of bitter melon (Momordica charantia) as a functional food to prevent and treat diabetes and associated complications. It is noteworthy to mention that bitter melon extract has no-to-low side effects in animals as well as in humans. The anti-tumor activity of bitter melon has recently begun to emerge. This review focuses on recent advancements in cancer chemopreventive and anti-cancer efficacy of bitter melon and its active constituents. Several groups of investigators have reported that treatment of bitter-melon-related products in a number of cancer cell lines induces cell cycle arrest and apoptosis without affecting normal cell growth. Therefore, the effect of bitter melon should be beneficial for health, and use of the non-modified dietary product is cost effective.