Dual thermo-responsive and ion-recognizable monodisperse microspheres
Dual thermo-responsive and ion-recognizable monodisperse microspheres
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双重热响应和离子可识别单分散微球
DOI：
10.1016/j.polymer.2008.12.022
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发表时间：
2009-01-28
期刊：
影响因子：
4.6
通讯作者：
Chu, Liang-Yin
中科院分区：
文献类型：
--
作者：
Ju, Xiao-Jie;Liu, Li;Chu, Liang-Yin
本研究制备了一种新型的双重刺激响应微球，该微球同时具有基于冠醚受体（苯并-18-冠-6-丙烯酰胺）（BCAm）与特定离子的超分子主客体络合作用的离子识别特性和基于聚（N-异丙基丙烯酰胺）（PNIPAM）相变的温度敏感性。采用红外光谱、紫外可见吸收光谱、扫描电镜、动态光散射等手段对所制备的聚（N-异丙基丙烯酰胺-co-苯并-18-冠-6-丙烯酰胺）（P（NIPAM-co-BCAm））微球进行了表征。SEM和DLS数据表明，合成的微球具有接近完美的球形和高的单分散性。此外，根据DLS结果，P（NIPAM-co-BCAm）微球表现出令人满意的温度响应行为和离子识别性能。在K+溶液中，由于冠醚/K+络合物的形成，P（NIPAM-co-BCAm）微球的LCST向高温移动，胶体稳定性提高。在一定温度下，随着金属离子的加入，P（NIPAMco-BCAm）微球的体积由收缩状态转变为等温溶胀网络状态。由于这种微球具有温度响应和离子识别的双重特性，它有望成为传感器、药物控释系统和新型生物材料的候选材料。(C)2008爱思唯尔有限公司保留所有权利。
A novel type of dual stimuli-responsive microspheres that simultaneously exhibit ion-recognition property based on the supramolecular host-guest complexation of crown ether receptors (benzo-18-crown-6-acrylamide) (BCAm) with specific ions and thermo-sensitivity based on the phase transition of poly(N-isopropylacrylamide) (PNIPAM) is fabricated in this study. The prepared poly(N-isopropylacrylamide-co-benzo-18-crown-6-acrylamide) (P(NIPAM-co-BCAm)) microspheres are characterized by FT-IR spectroscopy, UV-vis absorption spectroscopy, scanning electron microscopy (SEM), and dynamic light scattering (DLS). SEM images and DLS data show that the synthesized microspheres exhibit nearly perfect spherical shape and high monodispersity. Moreover, according to the DLS results, P(NIPAM-co-BCAm) microspheres exhibit satisfactory thermo-responsive behavior and ion-recognition property. In K+ solutions, due to the formation of crown ether/K+ complexes, the LCST of P(NIPAM-co-BCAm) microspheres shifts to a higher temperature and the colloidal stability is increased. The P(NIPAMco-BCAm) microspheres undergo a volume change from shrunken state to swollen network isothermally at a certain temperature by the addition of metal ions. Due to dual thermo-responsive and ion-recognition behaviors, this kind of microspheres would serve as promising candidates for sensors, controlled drug delivery systems and possibly new biomaterials. (C) 2008 Elsevier Ltd. All rights reserved.