Systemic blood flow to the lung after bronchial artery occlusion in anesthetized sheep.
Systemic blood flow to the lung after bronchial artery occlusion in anesthetized sheep.
复制标题
麻醉绵羊支气管动脉闭塞后全身血流至肺部。
DOI：
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发表时间：
1992
影响因子：
3.3
通讯作者：
P. Paré
中科院分区：
文献类型：
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作者：
E. Baile;D. Minshall;P. Harrison;P. Dodek;P. Paré
为了比较不同栓塞剂对减少或重新分配支气管动脉血流量的效果，我们用放射性微球法测定了麻醉绵羊右肺和右气管的血流量，分别为：BEA内注射乙醇4ml(组1，n=5)、聚乙烯醇颗粒(PVA)约0.5g(组2，n=5)或结扎BEA(组3，n=5)。闭塞后，血管造影显示支气管血管完全阻塞。两组患者的气管血流量均无明显变化。注射乙醇使流向中叶的血流量减少75+/-14%(P<0.02)，使流向尾叶的血流量减少75+/-13%(P<0.01)，而注射PVA使流向这两个肺叶的血流量减少较少(分别为41+/-66和51+/-54%)。BEA结扎后，流向中叶的流量减少了52+/-29%，流向尾叶的流量减少了53+/-38%(P<0.05)。这项研究具有重要的临床和实验意义；它阐明了呼吸道侧支循环的重要性，因为表面上完全的BEA放射学阻塞并不一定意味着全身血流的完全阻塞。我们还得出结论，在研究支气管循环在呼吸道病理生理学中的作用的实验研究中，无水乙醇是首选的药物。
To compare the effectiveness of different embolizing agents in reducing or redistributing bronchial arterial blood flow, we measured systemic blood flow to the right lung and trachea in anesthetized sheep by use of the radioactive microsphere method before and 1 h after occlusion of the bronchoesophageal artery (BEA) as follows: injection of 4 ml ethanol (ETOH) into BEA (group 1, n = 5), injection of approximately 0.5 g polyvinyl alcohol particles (PVA) into BEA (group 2, n = 5), or ligation of BEA (group 3, n = 5). After occlusion, angiography showed complete obstruction of the bronchial vessels. There were no changes in tracheal blood flow in any of the groups. Injection of ETOH produced a 75 +/- 14% (SD) reduction in flow to the middle lobe (P less than 0.02) and a 75 +/- 13% reduction to the caudal lobe (P less than 0.01), whereas injection of PVA produced a smaller reduction in flow to these two lobes (41 +/- 66 and 51 +/- 54%, respectively). After BEA ligation there was a 52 +/- 29% reduction in flow to the middle lobe and a 53 +/- 38% reduction to the caudal lobe (P less than 0.05). This study has significant implications both clinically and experimentally; it illustrates the importance of airway collateral circulation, in that apparently complete radiological obstruction of the BEA does not necessarily mean complete obstruction of systemic blood flow. We also conclude that, in experimental studies in which the role of the bronchial circulation in airway pathophysiology is examined, ETOH is the agent of choice.