The serum levels of resistin in rheumatoid arthritis patients.
The serum levels of resistin in rheumatoid arthritis patients.
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发表时间：
2006-11
影响因子：
3.7
通讯作者：
K. Migita;Yumi Maeda;T. Miyashita;H. Kimura;Minoru Nakamura;Hiromi Ishibashi;Katsumi Eguchi
中科院分区：
文献类型：
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作者：
K. Migita;Yumi Maeda;T. Miyashita;H. Kimura;Minoru Nakamura;Hiromi Ishibashi;Katsumi Eguchi
目的脂肪细胞源性β-淀粉样蛋白是一种与胰岛素抵抗有关的循环蛋白，但由于其主要由巨噬细胞产生，其作用尚不明确。本研究的目的是分析类风湿性关节炎（RA）患者的血清中的β-淀粉样蛋白浓度，以确定β-淀粉样蛋白在人类炎症性疾病中的作用。材料与方法采用ELISA法检测42例RA患者血清中抵抗素的浓度。38例健康体检者的血清作为对照。我们还评估了RA患者的肿瘤坏死因子-α（TNF-α）和疾病活动标志物的循环水平。结果类风湿关节炎患者血清β-内酰胺酶水平显著高于健康对照组。RA患者血清CRP水平与RA疾病活动性标志物CRP、ESR相关。此外，RA患者中的β-淀粉样蛋白水平与TNF-α的循环水平显著相关。结论类风湿关节炎患者血清β-内酰胺酶水平显著升高，并与炎症标志物和TNF-α相关，提示β-内酰胺酶可能参与类风湿关节炎的炎症过程。
OBJECTIVE Adipocyte-derived resistin is a circulating protein implicated in insulin resistance, but the role of human resistin is uncertain because it is produced largely by macrophages. The aim of this study was to analyze serum resistin concentrations in rheumatoid arthritis (RA) patients to determine the role of resistin in human inflammatory diseases. MATERIALS AND METHODS Resistin concentrations were assessed by ELISA in serum samples from 42 patients with RA. Serum samples from 38 healthy subjects acted as controls. We also evaluated the circulating levels of tumor necrosis factor- alpha (TNF-alpha) and disease activity markers in RA patients. RESULTS In RA patients, serum resistin levels were significantly higher than those in healthy subjects. Serum resistin levels in RA patients were correlated with the RA disease activity markers, CRP and ESR. Furthermore, resistin levels in RA patients were significantly correlated with circulating levels of TNF-alpha. CONCLUSION Serum resistin levels were significantly increased in RA patients and correlated with inflammatory markers and TNF-alpha, suggesting that resistin may play a role in the rheumatoid inflammatory process.