Serum leptin concentrations correlate to plasma insulin concentrations independent of body fat content in chronic renal failure
Serum leptin concentrations correlate to plasma insulin concentrations independent of body fat content in chronic renal failure
复制标题
DOI：
10.1093/ndt/12.7.1321
复制
发表时间：
1997-07-01
影响因子：
6.1
通讯作者：
Lonnqvist, F
中科院分区：
文献类型：
--
作者：
Stenvinkel, P;Heimburger, O;Lonnqvist, F
背景。ob基因产物瘦素由脂肪细胞分泌，反映体内脂肪含量。瘦素和胰岛素浓度以及体重是相互关联的，在肾功能正常的人体内，这些浓度之间已经发现了直接的相关性。最近有报道称慢性肾功能衰竭（CRF）患者血清瘦素浓度显著升高。本研究旨在探讨晚期慢性肾功能衰竭患者血清瘦素与血浆胰岛素的关系。对46例晚期CRF（肌酐清除率8 +/- ml/min）患者（平均年龄54 +/- 2岁）进行血清瘦素、血浆胰岛素和体脂含量测定（用双能x线吸收仪测定）。在23例血浆胰岛素低于中位数（14 mU/1）的CRF患者中，血清瘦素浓度不高于健康对照组（8.0 +/- 1.2 vs 8.4 +/- 0.9 ng/ml）。然而，在血浆胰岛素浓度为bb0 14mU/1 （n=23）的CRF患者中，血清瘦素浓度要高得多(38.2 +/- 11.0 ng/ml
Background. The ob gene product leptin is secreted by fat cells and reflects the content of fat in the body. Leptin and insulin concentrations as well as body weight are interrelated and a direct correlation has been found between these concentrations in humans with normal renal function. Markedly elevated serum leptin concentrations have recently been reported in patients with chronic renal failure (CRF). The aim of the present study was to investigate the relation between serum leptin and plasma insulin in patients with advanced CRF.Methods. Serum leptin, plasma insulin, as well as body fat content (determined with dual-energy X-ray absorptiometry) were determined in a cohort of 46 patients (mean age 54 +/- 2 years) with advanced CRF (creatinine clearance 8 +/- ml/min).Results. In 23 CRF patients with plasma insulin below the median value (14 mU/1), serum leptin concentrations were no higher than in healthy controls (8.0 +/- 1.2 vs 8.4 +/- 0.9 ng/ml). However, in CRF patients with plasma insulin >14mU/1 (n=23) the serum leptin concentrations were much higher (38.2 +/- 11.0 ng/ml; P