Roles of nucleolin. Focus on cancer and anti-cancer therapy.
Roles of nucleolin. Focus on cancer and anti-cancer therapy.
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DOI：
10.15537/smj.2016.12.15972
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发表时间：
2016-12
影响因子：
1.6
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Chen Z;Xu X
核仁素是一种多功能蛋白质，分布于细胞核中，参与rDNA转录、RNA代谢和核糖体组装等多种调控。核仁素也存在于细胞质和细胞膜上，并且表面核仁素可以与各种配体结合以影响许多生理功能。核仁素在肿瘤中的表达和定位往往是异常的，核仁素在肿瘤中的分布差异会影响癌细胞的发生、增殖、存活和转移，从而导致肿瘤的进展。因此，核仁素可能是一个新的和有前途的抗肿瘤治疗的目标。在这里，我们描述了核仁素如何在癌症发展中发挥作用，并描述了核仁素依赖性抗癌疗法。
Nucleolin, a multifunctional protein distributed in the nucleolus, participates in many modulations including rDNA transcription, RNA metabolism, and ribosome assembly. Nucleolin is also found in the cytoplasm and on the cell membrane, and surface nucleolin can bind to various ligands to affect many physiological functions. The expression and localization of nucleolin is often abnormal in cancers, as the differential distribution of nucleolin in cancer can influence the carcinogenesis, proliferation, survival, and metastasis of cancer cells, leading to the cancer progression. Thus, nucleolin may be a novel and promising target for anti-cancer treatment. Here, we describe how nucleolin act functions in cancer development and describe nucleolin-dependent anti-cancer therapies.