A key control point in the T cell response to chronic infection and neoplasia: FOXO1.
A key control point in the T cell response to chronic infection and neoplasia: FOXO1.
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DOI：
10.1016/j.coi.2020.02.001
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发表时间：
2020-04
影响因子：
7
通讯作者：
Hedrick SM
中科院分区：
文献类型：
--
作者：
Marcel N;Hedrick SM
能够控制肿瘤形成或慢性感染的T细胞显示出与中央记忆T细胞相似或相同的特征基因表达谱。这些细胞具有自我更新的性质和可塑性，使它们能够反复经历激活（生长，增殖和分化），然后静止。正是这些品质定义了T细胞与慢性感染因子建立平衡的能力，并且还保留了T细胞响应于恶性癌症而被重新激活（通过检查点疗法）的能力。在这里，我们描述了肿瘤和持久性病毒介导的抑制形式之间的区别，我们回顾了与长期免疫相关的T细胞的特性，我们确定了转录因子FOXO 1作为基因表达程序的控制点，该程序允许CD8+ T细胞进行连续的再激活和自我更新。
T cells able to control neoplasia or chronic infections display a signature gene expression profile similar or identical to that of central memory T cells. These cells have qualities of self-renewal and a plasticity that allow them to repeatedly undergo activation (growth, proliferation, and differentiation), followed by quiescence. It is these qualities that define the ability of T cells to establish an equilibrium with chronic infectious agents, and also preserve the ability of T cells to be re-activated (by checkpoint therapy) in response to malignant cancers. Here we describe distinctions between the forms of inhibition mediated by tumors and persistent viruses, we review the properties of T cells associated with long-term immunity, and we identify the transcription factor, FOXO1, as the control point for a program of gene expression that allows CD8+ T cells to undergo serial reactivation and self-renewal.
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DOI：
10.1016/j.jaci.2016.06.021
发表时间：
2017-02
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Coulter TI;Chandra A;Bacon CM;Babar J;Curtis J;Screaton N;Goodlad JR;Farmer G;Steele CL;Leahy TR;Doffinger R;Baxendale H;Bernatoniene J;Edgar JD;Longhurst HJ;Ehl S;Speckmann C;Grimbacher B;Sediva A;Milota T;Faust SN;Williams AP;Hayman G;Kucuk ZY;Hague R;French P;Brooker R;Forsyth P;Herriot R;Cancrini C;Palma P;Ariganello P;Conlon N;Feighery C;Gavin PJ;Jones A;Imai K;Ibrahim MA;Markelj G;Abinun M;Rieux-Laucat F;Latour S;Pellier I;Fischer A;Touzot F;Casanova JL;Durandy A;Burns SO;Savic S;Kumararatne DS;Moshous D;Kracker S;Vanhaesebroeck B;Okkenhaug K;Picard C;Nejentsev S;Condliffe AM;Cant AJ
通讯作者：
Cant AJ
影响因子：
5.4
作者：
Bupp, Melanie R. Gubbels;Edwards, Bonnie;Guo, Caiying;Wei, Datsen;Chen, Gang;Wong, Brian;Masteller, Emma;Peng, Stanford L.
通讯作者：
Peng, Stanford L.
影响因子：
8.8
作者：
Ban, Young Ho;Oh, Se-Chan;Ha, Sang-Jun
通讯作者：
Ha, Sang-Jun
影响因子：
--
作者：
Brown AK;Webb AE
通讯作者：
Webb AE
影响因子：
20.3
作者：
Abdollahpour, Hengameh;Appaswamy, Giridharan;Klein, Christoph
通讯作者：
Klein, Christoph