The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment.
The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment.
复制标题
DOI：
10.1016/bs.apha.2016.01.006
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Balu DT
中科院分区：
文献类型：
--
作者：
Balu DT
精神分裂症是一种严重的精神疾病，影响着全球近1%的人口。尽管精神分裂症的病因尚不确定，但它被认为是一种神经发育障碍，是由环境损害和遗传脆弱性共同导致的。在过去的20年里，许多研究学科的证据表明兴奋性信号传导的改变，特别是涉及N-甲基-D-天冬氨酸受体（NMDAR）功能减退，是精神分裂症疾病过程的关键因素。本文综述了NMDAR通道的结构与功能关系，以及甘氨酸调节位点（GMS）如何作为其活性的重要调节因子。此外，这篇综述强调了支持NMDAR功能减退与精神分裂症的病理生理学有关这一假设的遗传学、药理学和生化学证据。最后，本章强调了一些最新的和有前途的药理学策略，旨在直接或间接地增强NMDAR功能，以治疗目前可用药物无法帮助的精神分裂症的认知和阴性症状。
Schizophrenia is a severe mental illness that affects almost 1% of the population worldwide. Even though the etiology of schizophrenia is uncertain, it is believed to be a neurodevelopmental disorder that results from a combination of environmental insults and genetic vulnerabilities. Over the past 20 years, there has been a confluence of evidence from many research disciplines pointing to alterations in excitatory signaling, particularly involving hypofunction of the N-methyl-D-aspartate receptor (NMDAR), as a key contributor to the schizophrenia disease process. This review describes the structure-function relationship of the NMDAR channel and how the glycine modulatory site (GMS) acts as an important regulator of its activity. In addition, this review highlights the genetic, pharmacologic, and biochemical evidence supporting the hypothesis that NMDAR hypofunction contributes to the pathophysiology of schizophrenia. Finally, this chapter highlights some of the most recent and promising pharmacological strategies that are designed to either, directly or indirectly, augment NMDAR function in an effort to treat the cognitive and negative symptoms of schizophrenia that are not helped by currently available medications.
登录
查看更多内容
影响因子：
3.5
作者：
Balu, Darrick T.;Carlson, Gregory C.;Talbot, Konrad;Kazi, Hala;Hill-Smith, Tiffany E.;Easton, Rachel M.;Birnbaum, Morris J.;Lucki, Irwin
通讯作者：
Lucki, Irwin
影响因子：
11
作者：
Basu, A. C.;Tsai, G. E.;Coyle, J. T.
通讯作者：
Coyle, J. T.
影响因子：
14.5
作者：
Curcio, Livia;Podda, Maria V.;D'Ascenzo, Marcello
通讯作者：
D'Ascenzo, Marcello
影响因子：
4
作者：
Benneyworth MA;Li Y;Basu AC;Bolshakov VY;Coyle JT
通讯作者：
Coyle JT
影响因子：
8.2
作者：
Balu, Darrick T.;Coyle, Joseph T.
通讯作者：
Coyle, Joseph T.