Impaired immunologic reactivity and recurrence following cancer surgery
Impaired immunologic reactivity and recurrence following cancer surgery
复制标题
癌症手术后免疫反应受损和复发
作者：
F. Eilber;D. Morton
测试了100名患者对7种常见皮试抗原的反应能力以及对2，4-二硝基氯苯（DNCB）发生迟发型皮肤超敏反应的能力。致敏后，超过95%的正常患者，但只有60%的患者与潜在的可切除肿瘤，表现出迟发性皮肤过敏DNCB。提示对DNCB无反应与术后6个月内不可手术、局部复发或远处转移的发生率之间存在相关性。93%（27/29）对DNCB无反应的患者无法手术或出现早期复发，而92%（50/54）对DNCB有反应的患者6个月内无疾病;但这些患者中的许多人对所有常见的皮肤试验抗原均无反应。这些研究表明，细胞介导的免疫反应性（通过对DNCB的迟发性皮肤超敏反应测定）与确定性癌症手术后的恶性疾病病程之间存在显著相关性。
One hundred patients were tested for their ability to react to 7 commonly encountered skin test antigens and to develop delayed cutaneous hypersensitivity to 2, 4‐dinitrochlorobenzene (DNCB). Following sensitization, more than 95% of normal patients, but only 60% of patients with potentially resectable neoplasms, exhibited delayed cutaneous hypersensitivity to DNCB. A correlation is suggested between the inability to react to DNCB and the incidence of either inoperability, local recurrence, or distant metastases within 6 months post‐operatively. Ninety‐three percent (27/29) of patients who failed to react to DNCB were inoperable or developed early recurrence, whereas 92% (50/54) of patients who reacted to DNCB were free of disease for 6 months; but many of these patients were nonreactive to all of the common skin test antigens. These studies suggest that there is a significant correlation between cell mediated immunologic reactivity as measured by delayed cutaneous hypersensitivity to DNCB and the course of malignant disease following definitive cancer surgery.