Direct C-H Radiocyanation of Arenes via Organic Photoredox Catalysis.
Direct C-H Radiocyanation of Arenes via Organic Photoredox Catalysis.
复制标题
通过有机光氧化还原催化芳烃的直接 C-H 放射性氰化。
DOI：
10.1021/acs.orglett.2c03940
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发表时间：
2022
期刊：
影响因子：
5.2
通讯作者：
Li,Zibo
中科院分区：
文献类型：
--
作者：
Chen,Wei;Wu,Xuedan;McManus,JoshuaB;Bida,GeraldT;Li,Kang-Po;Wu,Zhanhong;Nicewicz,DavidA;Li,Zibo
Innovative labeling methods to incorporate the short-lived positron emitter carbon-11(11C) into bioactive molecules are attractive for positron emission tomography (PET) tracer discovery. Herein, we report a direct C–H radiocyanation method that incorporates [11C]cyanide (11CN–) to a series of functional electron-rich arenes via photoredox catalysis. This photoredox-mediated radiocyanation can proceed in an aerobic environment and is not moisture sensitive, which allows for ease of reaction setup and for scalable synthesis of11C-aryl nitriles from readily available precursors.
