Relative reward preference in primate orbitofrontal cortex
Relative reward preference in primate orbitofrontal cortex
复制标题
DOI：
10.1038/19525
复制
发表时间：
1999-04-22
期刊：
影响因子：
64.8
通讯作者：
Schultz, W
中科院分区：
文献类型：
--
作者：
Tremblay, L;Schultz, W
前额叶皮层的眶区似乎在目标导向行为的动机控制中起着至关重要的作用（1，2）。眶额皮质病变的患者在对行动的预期结果做出决定时表现出障碍（3）。患有眶额病变的猴子对奖励期望的变化反应异常（4，5），并表现出改变的奖励偏好（6）。由于奖励构成了行为的基本目标（7），我们在这里研究了猴子眶额皮层中的神经元如何在典型的额叶任务中处理关于液体和食物奖励的信息，空间延迟反应（8）。在预期奖励期间和收到奖励后，眶额神经元的活动会响应奖励预测信号而增加。神经元区分不同的奖励，主要是不考虑奖励预测刺激和行为反应的空间和视觉特征。大多数奖励歧视反映了动物在可用奖励中的相对偏好，如它们的选择行为所表达的，而不是物理奖励属性。因此，眶额皮层的神经元似乎处理了自愿行动的奖励结果的动机价值。
The orbital part of prefrontal cortex appears to be crucially involved in the motivational control of goal-directed behaviour(1,2). Patients with lesions of orbitofrontal cortex show impairments in making decisions about the expected outcome of actions(3). Monkeys with orbitofrontal lesions respond abnormally to changes in reward expectations(4,5) and show altered reward preferences(6). As rewards constitute basic goals of behaviour(7) we investigated here how neurons in the orbitofrontal cortex of monkeys process information about liquid and food rewards in a typical frontal task, spatial delayed responding(8). The activity of orbitofrontal neurons increases in response to reward-predicting signals, during: the expectation of rewards, and after the receipt of rewards. Neurons discriminate between different rewards, mainly irrespective of the spatial and visual features of reward-predicting stimuli and behavioural reactions. Most reward discriminations reflect the animals' relative preference among the available rewards, as expressed by their choice behaviour, rather than physical reward properties. Thus, neurons in the orbitofrontal cortex appear to process the motivational value of rewarding outcomes of voluntary action.