Quantitative estimation of attenuation in ultrasound video images - Correlation with histology in diffuse liver disease
Quantitative estimation of attenuation in ultrasound video images - Correlation with histology in diffuse liver disease
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DOI：
10.1097/00004424-200005000-00006
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发表时间：
2000-05-01
影响因子：
6.7
通讯作者：
Irving, CS
中科院分区：
文献类型：
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作者：
Graif, M;Yanuka, M;Irving, CS
理由和目标。确定肝脏 B 扫描图像中反向散射强度的衰减与弥漫性肝病之间的关系，以评估该方法在提供弥漫性肝病（特别是脂肪肝）的定量客观表征方面的有用性。方法。这项研究包括 24 名健康志愿者和 28 名接受肝活检的肝酶水平升高的患者。自动远场斜率 (FFS) 算法可估计反向散射回波幅度随波束深度的变化而减少的情况，该算法在安装到定制接口卡的商用相控阵超声系统上采集的非补偿图像上实现。图像在工作站上进行处理。所有扫描均由经验丰富的超声放射科医生盲目重复采集、读取和分级。在不了解超声结果的情况下对通过针吸活检获得的组织学进行了审查。结果。对所有患者组脂肪浸润的 FFS 数据进行分析，得出的敏感性为 67%，特异性为 77%，阳性预测值 (PPV) 为 77%，阴性预测值 (NPV) 为 67%，准确性为 71%。超声检查者的平均得分显示敏感性为 82%，特异性为 66%，PPV% 为 68%，NPV 为 81%，准确性为 72%。在 5 名经证实有脂肪浸润的患者中发现 FFS 值正常（假阴性）。所有这些患者都同时存在中度至重度肝脏炎症。然而，无并发症（纯）脂肪浸润患者的 FFS 数据显示敏感性为 100%，特异性为 80%，PPV 为 89%，NPV 为 100%，准确性为 92%。在同一患者中，最佳超声评分的敏感性为 100%，特异性为 60%，PPV 为 80%，NPV 为 100%，准确度为 85%。结论。数据表明，对于无并发症的脂肪浸润患者，FFS 值具有出色的敏感性 (100%)。这也是唯一一组 FFS 评分优于放射科医生最佳评分的患者。 FFS 方法可用作跟踪临床或研究治疗反应的工具，并独立于个体读者获得模式解释的标准化。
RATIONALE AND OBJECTIVES. To determine the relationship between the attenuation of backscatter intensity in B-scan images of the liver and diffuse liver disease in order to assess the usefulness of this method in providing quantitative objective characterization of diffuse liver diseases in general and in fatty liver in particular.METHODS. Twenty-four healthy volunteers and 28 patients with elevated liver enzyme levels who underwent liver biopsy were included in this study. An automatic far-field slope (FFS) algorithm that estimates the decrease in amplitude of the backscattered echo as a function of beam depth was implemented on the noncompensated image that was acquired on a commercial phased-array ultrasound system fitted to a custom-built interface card. The images were processed at a workstation. All scans mere acquired repeatedly, read, and graded blindly by experienced ultrasound radiologists. Histology obtained via needle biopsy was reviewed without knowledge of the ultrasound findings.RESULTS. Analysis of the FFS data for fatty infiltration in all patient groups yielded a sensitivity of 67%, a specificity of 77%, a positive predictive value (PPV) of 77%, negative predictive value (NPV) of 67%, and an accuracy of 71%. The mean score of the ultrasound reviewers showed a sensitivity of 82%, a specificity of 66%, a PPV% of 68%, an NPV of 81%, and an accuracy of 72%. Normal FFS values (false-negative) were found in five patients with proved fatty infiltration. All of these patients had coexistent moderate to severe hepatic inflammation. However, FFS data in patients with uncomplicated (pure) fatty infiltration revealed a sensitivity of 100%, a specificity: of 80%, a PPV of 89%, an NPV of 100%, and an accuracy of 92%. The best ultrasound score yielded a sensitivity of 100%, a specificity of 60%, a PPV of 80%, an NPV of 100%, and an accuracy of 85% in the same patients.CONCLUSIONS. The data demonstrate an excellent sensitivity (100%) of the FFS values in patients with uncomplicated fatty infiltration. This was also the only group of patients in whom the FFS score was superior to the radiologists' best score. The FFS method can be used as a tool to follow up the response to a clinical or research treatment and to obtain standardization of pattern interpretation independently of the individual reader.