Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins.
Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins.
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DOI：
10.1126/stke.2002.119.pe6
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发表时间：
2002-02-12
期刊：
影响因子：
--
通讯作者：
Ingber, Donald E
中科院分区：
文献类型：
--
作者：
Alenghat, Francis J;Ingber, Donald E
机械应力通过激活或调节信号转导通路来调节细胞功能。机械转导是细胞将机械刺激转化为化学反应的过程，既发生在专门感知机械信号的细胞中，也发生在主要功能不是机械感觉的实质细胞中。然而，在对机械应力的各种反应中，共同的是内部细胞骨架、细胞外基质（ECM）和传统信号转导分子之间直接或间接联系的重要性。在许多情况下，这些元素聚集在局灶黏附处，即细胞骨架和ECM之间的结构附着位点，由细胞表面整合素受体锚定。Alenghat和Ingber讨论了细胞骨架、ECM和整合素锚定的局灶粘连在几种机械转导途径中发挥核心作用的证据。
Mechanical stresses modulate cell function by either activating or tuning signal transduction pathways. Mechanotransduction, the process by which cells convert mechanical stimuli into a chemical response, occurs both in cells specialized for sensing mechanical cues and in parenchymal cells whose primary function is not mechanosensory. However, common among the various responses to mechanical stress is the importance of direct or indirect connections between the internal cytoskeleton, the extracellular matrix (ECM), and traditional signal transducing molecules. In many instances, these elements converge at focal adhesions, sites of structural attachment between the cytoskeleton and ECM that are anchored by cell surface integrin receptors. Alenghat and Ingber discuss the accumulating evidence for the central role of cytoskeleton, ECM, and integrin-anchored focal adhesions in several mechanotransduction pathways.