Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease
Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease
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DOI：
10.1016/j.neulet.2006.07.029
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发表时间：
2006-10-02
影响因子：
2.5
通讯作者：
Weiner, Michael
中科院分区：
文献类型：
--
作者：
Duarte, Audrey;Hayasaka, Satoru;Weiner, Michael
在阿尔茨海默病（AD）中，萎缩对认知产生负面影响，而在健康成人中，脑容量与认知之间可能出现反比关系。我们研究了老年对照、AD和轻度认知障碍（MCI）患者的灰质体积与认知的相关性。AD表现为颞叶、顶叶和额叶区域的大量体积损失，而MCI表现为颞叶和额叶区域的中度体积损失。在对照组中，记忆和执行功能与额叶区呈负相关，而在AD组中，记忆与颞叶和额叶回呈正相关，执行功能与额叶区呈正相关。这两种模式的结合可以解释MCI缺乏相关性的原因。对这些关系的发育和病理贡献进行了讨论。2006爱思唯尔爱尔兰有限公司版权所有。
In Alzheimer's disease (AD), atrophy negatively impacts cognition while in healthy adults, inverse relationships between brain volume and cognition may occur. We investigated correlations between gray matter volume and cognition in elderly controls, AD and mild cognitive impairment (MCI) patients with memory and executive deficits. AD demonstrated substantial loss in temporal, parietal and frontal regions while MCI exhibited moderate volume loss in temporal and frontal regions. In controls, memory and executive function were negatively correlated with frontal regions, while in AD, memory was positively correlated with temporal and frontal gyri, and executive function with frontal regions. The combination of the two patterns may explain the lack of correlations in MCI. Developmental versus pathological contributions to these relationships are discussed. (c) 2006 Elsevier Ireland Ltd. All rights reserved.