Hyperpolarized 3-helium magnetic resonance imaging to probe lung function.
Hyperpolarized 3-helium magnetic resonance imaging to probe lung function.
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DOI：
10.1513/pats.200507-071ds
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Wild, Jim M
中科院分区：
文献类型：
--
作者：
van Beek, Edwin J R;Wild, Jim M
了解肺部病理生理学对影像诊断有越来越重要的意义。尽管过去进行高分辨率计算机断层扫描就足够了，但现在的动力是提供定量和功能性的肺部数据。磁共振成像传统上很难在肺部进行，现在已经发展成为一项很有前途的技术。感兴趣的主要领域之一是使用超极化惰性气体，如3-He和129-Xe，这使得能够进行包括肺微结构信息的高清晰度肺成像。可以获得有关基本肺过程的三维信息，如呼吸、摄氧量和肺活量测定，这为肺病理生理学提供了新的见解。本文着重于超极化3-He磁共振成像的新方面。
Understanding pulmonary pathophysiology has increasing implications for imaging modalities. Although it was sufficient to perform high-resolution computed tomography in the past, the impetus now is on providing quantitative and functional lung data. Magnetic resonance imaging, which was traditionally difficult to perform in the lungs, has developed into a promising technology. One of the main areas of interest is the use of hyperpolarized noble gases, such as 3-He and 129-Xe, which enable high-definition lung imaging that includes information on lung microstructure. It is possible to obtain three-dimensional information on essential pulmonary processes, such as ventilation, oxygen uptake, and spirometry, which offers new insight into lung pathophysiology. This article focuses on the novel aspects of hyperpolarized 3-He magnetic resonance imaging.