Integration of Adenylate Kinase and Glycolytic and Glycogenolytic Circuits in Cellular Energetics
Integration of Adenylate Kinase and Glycolytic and Glycogenolytic Circuits in Cellular Energetics
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细胞能量学中腺苷酸激酶与糖酵解和糖原分解回路的整合
DOI：
10.1002/9783527621095.ch8
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
A. Terzic
中科院分区：
文献类型：
--
作者：
P. Dzeja;Susan Chung;A. Terzic
新出现的证据表明，腺苷酸激酶和糖酵解/糖原分解磷酸转移酶回路是心脏系统生物能量学的重要组成部分，通过提供高能磷酸化和将能量需求信号传递给ATP生成途径和代谢传感器在肌肉能量学中发挥重要作用。腺苷酸激酶磷酸转移迅速响应代谢失衡，促进ATP分子的gandbphosphoryls的转移和利用，并保持能量经济。腺苷酸激酶介导的细胞内AMP信号传导与AMP响应元件如AMP敏感性蛋白激酶（AMPK）、ATP敏感性钾通道（KATP）和AMP敏感性代谢酶偶联，沿着腺苷信号传导，构成调节重要细胞过程的关键代谢传感系统。腺苷酸激酶催化的AMP信号产生和核苷酸交换位于代谢传感器附近，调节亲密传感区中配体转换的动力学和频率，促进细胞信息的解码。通过激发AMP信号传导，腺苷酸激酶调节糖酵解和糖原分解酶的活性，并为生物能量途径提供整合节点，以高保真度响应增加的能量需求。胞质AK 1亚型的遗传缺陷导致肌肉能量和AMP信号传导缺陷，损害对代谢应激的反应。糖酵解途径的空间延伸表明，它包括一个网络的磷酸转移电路和代谢物穿梭，这有利于高能量的磷酰基输送和乳酸/丙酮酸和Pi穿梭，从而维持细胞的能量和氧化还原平衡。糖原利用和合成的动力学过程发生在肌原纤维和线粒体区室附近，也表明存在糖原分解的能量回路。在所提出的糖原能量网络模型中，线粒体代谢能量通过局部产生的UTP和G-6-P/G-1-P投入糖原，在肌原纤维和其他细胞隔室中的ATP利用位点的糖原分解期间释放。因此，不同的能量和代谢的系统集成265分子系统生物能量学：生命的能量。Edited by Valdur Saks Copyright 8 2007 WILEY-VCH Verlag GmbH & Co. KGaA，魏因海姆ISBN：978-3-527-31787-5信号通路确保细胞能量稳态和对广泛的功能活动和压力挑战的充分反应。
Emerging evidence indicates that adenylate kinase and glycolytic/glycogenolytic phosphotransfer enzyme circuits are essential parts of cardiac system bioenergetics, playing a significant role in muscle energetics by delivering high-energy phosphoryls and conveying energy demand signals to ATP-generating pathways and metabolic sensors. Adenylate kinase phosphotransfer promptly responds to metabolic imbalances, facilitating transfer and utilization of both gand bphosphoryls of the ATP molecule and maintaining energy economy. Adenylate kinase–mediated intracellular AMP signaling coupled with AMP-responsive elements such as AMP-sensitive protein kinase (AMPK), ATP-sensitive potassium channels (KATP), and AMP-sensitive metabolic enzymes, along with adenosine signaling, comprise a key metabolic sensing system regulating vital cellular processes. Localized in close proximity to metabolic sensors, adenylate kinase– catalyzed AMP signal generation and nucleotide exchange regulate the dynamics and frequency of ligand switching in the intimate sensing zone, facilitating the decoding of cellular information. By instigating AMP signaling, adenylate kinase regulates the activity of glycolytic and glycogenolytic enzymes and provides an integrative node for bioenergetic pathways to respond with high fidelity to increased energy demand. Genetic deficiency of the cytosolic AK1 isoform results in defective muscle energetics and AMP signaling, compromising the response to metabolic stress. Spatial extension of the glycolytic pathway indicates that it comprises a network of phosphotransfer circuits and metabolite shuttles, which facilitate high-energy phosphoryl delivery and lactate/pyruvate and Pi shuttling and thus maintain cellular energy and redox balance. The dynamics of glycogen utilization and synthesis, processes that occur close to myofibrillar and mitochondrial compartments, also suggest the existence of a glycogenolytic energetic circuit. In the proposed glycogen energetic network model, mitochondrial metabolic energy, invested into glycogen through locally generated UTP and G-6-P/G-1-P, is released during glycogenolysis at ATP utilization sites in myofibrils and other cellular compartments. Thus, systemic integration of different energetic and metabolic 265 Molecular System Bioenergetics: Energy for Life. Edited by Valdur Saks Copyright 8 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim ISBN: 978-3-527-31787-5 signaling pathways ensures cellular energy homeostasis and an adequate response to a broad range of functional activities and stress challenges.
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影响因子：
3.3
作者：
Rubin, LJ;Magliola, L;Hale, CC
通讯作者：
Hale, CC
DOI：
10.1002/9780470123195.ch4
发表时间：
1999-01-01
期刊：
ADVANCES IN ENZYMOLOGY, VOL 73
影响因子：
--
作者：
Yan, HG;Tsai, MD
通讯作者：
Tsai, MD
影响因子：
9.8
作者：
Burwinkel, B;Scott, JW;Kilimann, MW
通讯作者：
Kilimann, MW
体内羔羊心肌单向 P(i)-->ATP 通量的测量。
DOI：
10.1016/0005-2728(94)90213-5
发表时间：
1994
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Portman,MA
通讯作者：
Portman,MA
通过 13C-NMR 研究葡萄糖和糖原利用途径的同时和可分离通量。
影响因子：
5
作者：
Hardin,CD;Kushmerick,MJ
通讯作者：
Kushmerick,MJ