Dynamical quorum sensing: Population density encoded in cellular dynamics
Dynamical quorum sensing: Population density encoded in cellular dynamics
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DOI：
10.1073/pnas.0706089104
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发表时间：
2007-11-20
影响因子：
11.1
通讯作者：
Sorensen, Preben Graae
中科院分区：
文献类型：
--
作者：
De Monte, Silvia;d'Ovidio, Francesco;Sorensen, Preben Graae
通过交换化学物质而相互同步是细胞种群中集体动态出现的一种机制。关于向连贯的转变存在着一般的理论，但还没有给出定量的实验证明。在这里，我们提出了酵母中依赖细胞密度的糖酵解振荡的建模和实验分析。我们研究了在低细胞密度下振荡的消失，并表明这种现象在所有细胞中是同步发生的，而不是像之前预期的那样通过克隆同步发生。这项研究确定了集体细胞振荡出现的一般情景，并提出了一种群体感应机制，通过该机制，细胞密度信息在细胞内动态中被编码。
Mutual synchronization by exchange of chemicals is a mechanism for the emergence of collective dynamics in cellular populations. General theories exist on the transition to coherence, but no quantitative, experimental demonstration has been given. Here, we present a modeling and experimental analysis of cell-density-dependent glycolytic oscillations in yeast. We studythe disappearance of oscillations at low cell density and show that this phenomenon occurs synchronously in all cells and not by clesynchronization, as previously expected. This study identifies a general scenario for the emergence of collective cellular oscillations and suggests a quorum-sensing mechanism by which the cell density information is encoded in the intracellular dynamical state.