MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes.
MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes.
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MPTP 诱发中年食蟹猴系统性帕金森病：临床演变和结果。
DOI：
10.1007/s12264-016-0069-y
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Chan Piu
中科院分区：
文献类型：
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作者：
Yue Feng;Zeng Sien;Tang Rongping;Tao Guoxian;Chan Piu
在本研究中，我们利用个体化小剂量MPTP建立了中年食蟹猴全身性帕金森病模型，以探索早期预测临床结果的有效指标。直到动物在给药后第10~13天表现出典型的PD运动症状，当Kurlan评分达到10时，MPTP才停止；这消除了个体对MPTP易感性的差异。临床症状持续存在，停药后第3~12天达高峰(快速进展期)，随后Kurlan评分趋于平稳。快速进展阶段结束时的Kurlan评分为15分，表明帕金森病稳定或进展缓慢，而15分表示帕金森病自然恢复。这项研究描述了系统性帕金森病模型的整个临床演变和结果，从而为治疗性和转化性研究提供了选择。
In this study, we developed a systemic PD model in middle-aged cynomolgus monkeys using individualized low-dose MPTP, to explore effective indicators for the early prediction of clinical outcomes. MPTP was not stopped until the animals showed typical PD motor symptoms on days 10 to 13 after MPTP administration when the Kurlan score reached 10; this abrogated the differences in individual susceptibility to MPTP. The clinical symptoms persisted, peaking on days 3 to 12 after MPTP withdrawal (rapid progress stage), and then the Kurlan score plateaued. A Kurlan score at the end of the rapid progress stage >15 reflected stable or slowly-progressive PD, while a score <15 indicated spontaneous recovery. The entire clinical evolution and outcome of the systemic PD model was characterized in this study, thus providing options for therapeutic and translational research.