Upconversion nanocomposites for photo-based cancer theranostics.
Upconversion nanocomposites for photo-based cancer theranostics.
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DOI：
10.1039/c6tb00709k
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发表时间：
2016-08
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影响因子：
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通讯作者：
Shuailiang Wang;Anyao Bi;Wenbin Zeng;Zhen Cheng
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文献类型：
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作者：
Shuailiang Wang;Anyao Bi;Wenbin Zeng;Zhen Cheng
已知镧系离子掺杂的上转换纳米粒子（UCNPs）能够将长波激发光（通常为980 nm）转化为高能紫外（UV）或可见光，并且由于其独特的光化学性质，包括尖锐的发射带，低自身荧光，高组织穿透深度，对环境干扰的惰性以及对组织的最小光损伤，引起了人们的广泛关注。到目前为止，UCNPs在生物成像、生物传感和生物医学应用等各个领域显示出巨大的潜力。特别是近年来，基于UCNP的纳米复合材料被发现是多模态成像和低侵入性肿瘤光基治疗的有前途的工具。本文综述了近年来基于UCNP的多功能纳米平台在生物成像和癌症光疗方面的研究进展，包括光动力治疗（PDT）和光热治疗（PTT）。此外，还讨论了这一快速发展领域的一些新趋势、未来发展方向以及面临的挑战。
Lanthanide ion doped upconversion nanoparticles (UCNPs) are known to be able to convert long-wavelength excitation light (usually 980 nm) into high-energy ultraviolet (UV) or visible emissions, and they have attracted significant attention because of their distinct photochemical properties including sharp emission bands, low autofluorescence, high tissue penetration depth, inertness to ambient interference and minimal photodamage to tissues. Until now, UCNPs have shown great potential in various realms including bioimaging, biosensing and biomedical applications. Especially in recent years, UCNP based nanocomposites have been found to be promising tools for multi-modal imaging and low-invasive photo-based therapy of tumors. In this review, we summarize the recent achievement and progress of UCNP based multifunctional nanoplatforms for bioimaging and cancer phototheranostics, including photodynamic therapy (PDT) and photothermal therapy (PTT). Furthermore, some emerging trends, future directions as well as challenges in this rapidly growing field are discussed.