Positive placental staining for alkaline phosphatase corresponding with extreme elevation of serum alkaline phosphatase during pregnancy
Positive placental staining for alkaline phosphatase corresponding with extreme elevation of serum alkaline phosphatase during pregnancy
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DOI：
10.1007/s00404-006-0212-5
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发表时间：
2007-03-01
影响因子：
2.6
通讯作者：
Mazor, Moshe
中科院分区：
文献类型：
--
作者：
Bashiri, Asher;Katz, Ohad;Mazor, Moshe
胎盘ALP（ALP(h)）是一种膜锚定的热稳定酶，由合胞滋养细胞产生。我们报告一个病例的病人提出在孕晚期与极端增加水平的ALPh。一名40岁妇女，妊娠2期，第1段，在妊娠30周时被送入高危妊娠病房，以评估偶然发现的血清ALPh显著升高。入院时进行的血液检查显示血清ALP水平明显升高，高达1,194 u/l（参考文献35-104 u/l）。在妊娠36周时，患者因胎膜早破入院。由于臀位出现，我们进行了剖宫产。胎盘碱性磷酸酶免疫过氧化物酶染色，多数绒毛膜滋养细胞碱性磷酸酶阳性。胎盘毛膜板未见炎症迹象。因此，孤立的胎盘ALP升高可能与随后的早产有关。
Placental ALP (ALP(h)) is a membrane-anchored, heat-stable enzyme produced by the syncytiotrophoblast. We report a case of a patient presenting in the third trimester with extreme increased levels of ALPh. A 40-year-old woman, gravida 2, para 1, was admitted to the high risk pregnancy unit at 30 weeks of gestation for evaluation of an incidental finding of marked isolated elevation in serum ALPh. Blood tests obtained at admission revealed a marked elevation of serum ALP level up to 1,194 u/l (reference 35-104 u/l). At 36 weeks of gestation, the patient was admitted with preterm premature rupture of membranes. Due to breech presentation, a cesarean delivery was performed. An immunoperoxidase stain was done for placental alkaline phosphatase, which was positive in the majority of chorionic trophoblastic cells. No evidence of inflammation was detected in the placental chorionic plate. Thus, isolated elevation in placental ALP may be linked to a subsequent preterm delivery.