Conditioning factors in drug abuse: can they explain compulsion?
Conditioning factors in drug abuse: can they explain compulsion?
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DOI：
10.1177/026988119801200103
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发表时间：
1998-03-01
影响因子：
4.1
通讯作者：
Robbins, SJ
中科院分区：
文献类型：
--
作者：
O'Brien, CP;Childress, AR;Robbins, SJ
有大量的临床证据表明，强迫恢复吸毒是成瘾综合征的一个重要组成部分。对人类受试者进行了实验研究，发现了包括恢复吸毒动机在内的症状，即渴望和强迫。虽然还有很多工作要做，但有证据表明这些症状受到学习的影响。这项研究是在动物研究的指导下进行的，动物研究表明药物的作用是有条件的。许多注意力都集中在证明人类成瘾者中存在药物条件反射，并探索可能导致这种学习反应的神经结构上，我们还不知道学习在复发的整体现象中的相对重要性，基于条件反射原则的治疗仍在调查中。
There is a good deal of clinical evidence suggesting that compulsion to resume drug taking is an important part of the addiction syndrome. The symptoms comprising motivation to resume drug use, namely craving and compulsion, have been studied experimentally in human subjects. While much work remains to be done, there is evidence showing that these symptoms are influenced by learning. The research has been guided by animal studies demonstrating that drug effects can be conditioned. Much attention has been directed toward demonstrating the existence of drug conditioning in human addicts and exploring the neurological structures that may underlie such learned responses,We do not yet know the relative importance of learning in the overall phenomenon of relapse, and treatments based on conditioning principles are still under investigation.