Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer films
Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer films
复制标题
DOI：
10.1002/pi.6089
复制
发表时间：
2020-08-06
影响因子：
3.2
通讯作者：
Hardy, John G.
中科院分区：
文献类型：
--
作者：
Ashton, Mark D.;Appen, Isabel C.;Hardy, John G.
刺激响应药物输送系统的发展为行业创新提供了重要机会。可以生产基于聚合物的药物输送装置，从而能够时空控制由电刺激触发的药物的释放。在这里，我们描述了一种用于基于导电/电活性聚合物的生物材料进行药物输送的无线控制器的开发，并展示了其体外功能。无线聚合物传导控制器设备使用非常低的功率，工作频率为2.4 GHz，并且具有控制电刺激电压水平的电源电压控制器电路。计算机图形用户界面程序与控制器设备通信，并且其从控制器设备接收设备信息、设备状态和温度数据。无线控制器系统的原型可以触发从可降解电活性聚合物基质中释放药物磷酸地塞米松。此外，我们介绍了硅毒性筛选的应用，作为一种潜在有用的方法，以促进多种生物技术应用的无毒可降解电活性聚合物的设计，根据“设计安全”原则解决生物材料开发的关键商业挑战之一。 (c) 2020 The Authors.Polymer International 由 John Wiley & Sons Ltd 代表工业化学学会出版。
The development of stimuli-responsive drug delivery systems offers significant opportunities for innovations in industry. It is possible to produce polymer-based drug delivery devices enabling spatiotemporal control of the release of the drug triggered by an electrical stimulus. Here we describe the development of a wireless controller for drug delivery from conductive/electroactive polymer-based biomaterials and demonstrate its functionin vitro. The wireless polymer conduction controller device uses very low power, operating at 2.4 GHz, and has a supply voltage controller circuit which controls electrical stimulation voltage levels. The computer graphical user interface program communicates with the controller device, and it receives device information, device status and temperature data from the controller device. The prototype of the wireless controller system can trigger the delivery of a drug, dexamethasone phosphate, from a matrix of degradable electroactive polymers. Furthermore, we introduce the application ofin silicotoxicity screening as a potentially useful method to facilitate the design of non-toxic degradable electroactive polymers for a multitude of biotechnological applications, addressing one of the key commercial challenges to biomaterial development, in accordance with 'safe by design' principles. (c) 2020 The Authors.Polymer Internationalpublished by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.