The second outbreak of trichinellosis caused by Trichinella papuae in Thailand
The second outbreak of trichinellosis caused by Trichinella papuae in Thailand
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DOI：
10.1016/j.trstmh.2009.12.005
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发表时间：
2010-06-01
影响因子：
2.2
通讯作者：
Waikagu, Jitra
中科院分区：
文献类型：
--
作者：
Kusolsuk, Teera;Kamonrattanakun, Suthida;Waikagu, Jitra
2007年9月，泰国乌泰他尼省发生一起由丘疹旋毛虫引起的人类旋毛虫病暴发疫情，共收集34名至少有一种旋毛虫病疑似症状或无症状但有食用生野猪肉史的村民作为研究对象。22名村民吃下了一只被猎杀的野猪（Sus scrofa）的未煮熟的猪肉。1例临床表现严重的患者住院治疗，肌肉活检中检测到80多条无包囊幼虫。经鉴定，该幼虫为T.通过对线粒体细胞色素c氧化酶亚基I（CO 1）基因和大亚基rRNA的扩展片段5（ES 5）的分子分析，在34名疑似病例中，27人同意接受血液学和血清学检测。使用来自T.旋毛虫肌幼虫在26份血清样品中的20份中显示抗旋毛虫IgG（1份血清样品无法分析）。所有感染者均成功地用甲苯咪唑治疗; 1例严重泌尿系疾病患者成功地用泼尼松龙治疗。(C)2009年皇家热带医学和卫生学会。由爱思唯尔有限公司出版。保留所有权利。
A human trichinellosis outbreak caused by Trichinella papuae occurred in the Uthai Thani Province of Thailand in September 2007.A total of 34 villagers suffering at least one of the symptoms suggestive of trichinellosis, or those who were asymptomatic but had a history of ingesting raw wild pig meat, were enrolled in the study. Twenty-two villagers had ingested undercooked pork from a hunted wild pig (Sus scrofa). One patient with a severe clinical picture was hospitalised and more than 80 non-encapsulated larvae were detected in the muscle biopsy. The larvae were identified as T. papuae by molecular analyses of the mitochondrial cytochrome c oxidase subunit I (CO1) gene and the expansion segment 5 (ES5) of the large subunit rRNA. Of the 34 suspected cases, 27 agreed to be subjected to haematological and serological tests. Immunoblot analysis using crude antigens from T. spiralis muscle larvae revealed anti-Trichinella IgG in 20 of the 26 serum samples (1 serum sample could not be analysed). All infected people were successfully treated with mebendazole; the one patient with severe symptomatology was treated successfully with prednisolone. (C) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.