Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes
Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes
复制标题
负载近红外染料/光敏剂的脂质体可激活光动力破坏癌细胞
DOI：
10.1039/c4cc09689d
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Hu, Yiqiao
中科院分区：
文献类型：
--
作者：
Yuan, Ahu;Tang, Xiaolei;Hu, Yiqiao
近红外（NIR）染料吲哚菁绿（ICG）可有效抑制光动力治疗（PDT）中氯e6 （Ce6）的光毒性。在808 nm的近红外激光照射下，含有ICG和Ce6的脂质体中的ICG可以被降解，而Ce6的光毒性可以恢复。此外，我们证明了这种新开发的脂质体成分可以成功地用于体外激活PDT来破坏癌细胞。
The phototoxicity of Chlorin e6 (Ce6) for photodynamic therapy (PDT) was found to be effectively suppressed by indocyanine green (ICG), a near infrared (NIR) dye. Upon NIR laser irradiation at 808 nm, ICG in the liposomes containing ICG and Ce6 could be degraded, while the phototoxicity of Ce6 could be recovered. In addition, we demonstrate that this newly developed liposomal component can be successfully used for activatable PDT to destroy cancer cells in vitro.