Efficacy-oriented compatibility for component-based Chinese medicine
Efficacy-oriented compatibility for component-based Chinese medicine
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DOI：
10.1038/aps.2015.8
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发表时间：
2015-06-01
影响因子：
8.2
通讯作者：
Zhang, Bo-li
中科院分区：
文献类型：
--
作者：
Zhang, Jun-hua;Zhu, Yan;Zhang, Bo-li
对于涉及多因素的复杂疾病，单靶点药物尚未取得令人满意的治疗效果。相反，最近药物研发的创新揭示了复合药物的出现，如鸡尾酒疗法和“多药药丸”，成为新药开发的前沿。中药方剂是中药复方的典型代表，通常由几种中草药组成。传统的中药配伍理论虽然不能用现代科学语言表达，但其根本目的可以理解为增效减毒。本文介绍了以功效为导向的中药复方配伍理论和方法。
Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and "polypills", as the frontier in new drug development. A traditional Chinese medicine (TCM) prescription that is usually composed of several medicinal herbs can serve a typical representative of compound medicines. Although the traditional compatibility theory of TCM cannot be well expressed using modern scientific language nowadays, the fundamental purpose of TCM compatibility can be understood as promoting efficacy and reducing toxicity. This paper introduces the theory and methods of efficacy-oriented compatibility for developing component-based Chinese medicines.