Of Mice and Men: The Need for Humanized Mouse Models to Study Human IgG Activity in Vivo
Of Mice and Men: The Need for Humanized Mouse Models to Study Human IgG Activity in Vivo
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DOI：
10.1007/s10875-012-9782-0
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发表时间：
2013-01-01
影响因子：
9.1
通讯作者：
Nimmerjahn, Falk
中科院分区：
文献类型：
--
作者：
Lux, Anja;Nimmerjahn, Falk
IgG同种型的抗体具有多种促炎和抗炎效应子功能，使其成为开发新型治疗方法的有吸引力的平台。动物模型系统对于理解IgG活性的潜在机制是非常宝贵的。然而，IgG亚类和负责介导IgG依赖性效应子功能的Fc受体的差异，即使在人类和猴等密切相关的物种之间，也使得难以预测人IgG的体内活性。本次审查将集中在目前可用的动物模型系统用于研究人类IgG的活性，并提出新的模型系统，可能使我们能够获得更密切的关注在体内的分子和细胞机制的基础上的人类IgG活性。
Antibodies of the IgG isotype have a variety of pro- and anti-inflammatory effector functions, making them attractive platforms for the development of novel therapeutic approaches. Animal model systems have been invaluable to the understanding of the underlying mechanisms of IgG activity. However, differences in the IgG subclasses and Fc receptors responsible for mediating IgG-dependent effector functions, even between such closely related species as humans and monkeys, make it difficult to predict the activity of human IgG in vivo. This review will focus on currently available animal model systems used to study human IgG activity and will propose novel model systems that might enable us to obtain a closer look at the molecular and cellular mechanisms underlying human IgG activity in vivo.