Lack of dietary calcium effect on chlordecone increased white blood cell count, total iron, and iron-binding capacity in serum of rat.
Lack of dietary calcium effect on chlordecone increased white blood cell count, total iron, and iron-binding capacity in serum of rat.
复制标题
膳食钙缺乏对十氯酮的影响会增加大鼠血清中的白细胞计数、总铁和铁结合能力。
DOI：
10.1006/eesa.1996.0034
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Ivie,GW
中科院分区：
文献类型：
--
作者：
Chetty,KN;Fantroy,L;Landau,G;Ivie,GW
雄性Sprague-Dawley大鼠连续15天分别在钙充足（Ca-S）或钙缺乏（Ca-D）的饮食中混合了0、1、10、50和100 ppm的十氯酮（Cd）。与Ca-S饲料喂养的大鼠相比，Ca-D饲料喂养的对照大鼠表现出白色血细胞（WBC）计数的显著增加。然而，膳食钙（Ca），并没有引起任何显着的影响，总铁含量和铁结合能力（转铁蛋白）的对照组大鼠，而镉在较高浓度显着增加白细胞计数，总铁，和铁结合能力在血清中的Ca-S和Ca-D大鼠。这些数据表明，膳食钙并没有改变镉增加白细胞计数，总铁，血清铁结合力。
Male Sprague–Dawley rats were treated with 0, 1, 10, 50, and 100 ppm of chlordecone (Cd) mixed in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days. The control rats fed with Ca-D diet exhibited a significant increase in white blood cell (WBC) counts compared to the rats fed with Ca-S diet. Dietary calcium (Ca), however, did not elicit any significant effect on total iron content and iron-binding capacity (transferrin) of control rats, whereas Cd at higher concentrations significantly increased WBC counts, total iron, and iron-binding capacity in serum of both Ca-S and Ca-D rats. The data suggest that dietary Ca did not alter Cd-increased WBC count, total iron, and iron-binding capacity in serum of rat.