Stimulus-Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy.
Stimulus-Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy.
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DOI：
10.1002/smll.202206929
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发表时间：
2023-03
期刊：
影响因子：
13.3
通讯作者：
Qi Jiang;Shufang Zhang
中科院分区：
文献类型：
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作者：
Qi Jiang;Shufang Zhang
骨关节炎（OA）是最常见的与年龄相关的退行性疾病之一。随着全球人口日益老龄化，越来越多的OA患者正在带来明显的经济和社会负担。手术和药物治疗是OA最常见和传统的治疗策略，但往往远远达不到理想的或最佳的结果。随着刺激反应纳米平台的发展，OA的治疗策略有了改善的潜力。增强的控制、更长的保持时间、更高的加载速率和更高的灵敏度都是潜在的好处。本文综述了刺激响应型给药纳米平台在OA治疗中的最新应用，分为依赖内源性刺激（活性氧、pH、酶和温度）和依赖外源性刺激（近红外线、超声、磁场）的两类。与这些不同的药物传递系统或其组合相关的机会、限制和限制，将在多功能、图像引导和多刺激反应等领域进行讨论。最后总结了刺激反应性药物递送纳米平台临床应用所代表的其他限制和潜在解决方案。
Osteoarthritis (OA) is one of the most prevalent age-related degenerative diseases. With an increasingly aging global population, greater numbers of OA patients are providing clear economic and societal burdens. Surgical and pharmacological treatments are the most common and conventional therapeutic strategies for OA, but often fall considerably short of desired or optimal outcomes. With the development of stimulus-responsive nanoplatforms has come the potential for improved therapeutic strategies for OA. Enhanced control, longer retention time, higher loading rates, and increased sensitivity are among the potential benefits. This review summarizes the advanced application of stimulus-responsive drug delivery nanoplatforms for OA, categorized by either those that depend on endogenous stimulus (reactive oxygen species, pH, enzyme, and temperature), or those that depend on exogenous stimulus (near-infrared ray, ultrasound, magnetic fields). The opportunities, restrictions, and limitations related to these various drug delivery systems, or their combinations, are discussed in areas such as multi-functionality, image guidance, and multi-stimulus response. The remaining constraints and potential solutions that are represented by the clinical application of stimulus-responsive drug delivery nanoplatforms are finally summarized.