Cerebellar involvement in an evidence-accumulation decision-making task.
Cerebellar involvement in an evidence-accumulation decision-making task.
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DOI：
10.7554/elife.36781
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发表时间：
2018-08-13
期刊：
影响因子：
7.7
通讯作者：
Wang SS
中科院分区：
文献类型：
--
作者：
Deverett B;Koay SA;Oostland M;Wang SS
为了做出成功的基于证据的决策，大脑必须快速准确地将感官输入转化为特定的目标导向行为。关于这个主题的大多数实验工作都集中在前脑机制上。使用小鼠的新证据积累任务，我们对小脑外侧后小腿 I 进行了记录和扰动研究，该小腿与许多前脑区域进行双向通信。小脑失活导致正确试验的比例减少。使用钙的双光子荧光成像，我们发现浦肯野细胞体细胞活动包含选择/证据相关信息。决策错误以树突状钙尖峰为代表，在其他情况下，树突状钙尖峰会驱动小脑可塑性。我们认为小脑电路可能有助于支持这种感知决策任务的准确表现的计算。
To make successful evidence-based decisions, the brain must rapidly and accurately transform sensory inputs into specific goal-directed behaviors. Most experimental work on this subject has focused on forebrain mechanisms. Using a novel evidence-accumulation task for mice, we performed recording and perturbation studies of crus I of the lateral posterior cerebellum, which communicates bidirectionally with numerous forebrain regions. Cerebellar inactivation led to a reduction in the fraction of correct trials. Using two-photon fluorescence imaging of calcium, we found that Purkinje cell somatic activity contained choice/evidence-related information. Decision errors were represented by dendritic calcium spikes, which in other contexts are known to drive cerebellar plasticity. We propose that cerebellar circuitry may contribute to computations that support accurate performance in this perceptual decision-making task.