The Clinical Characteristics of Anisakis Allergy in Korea
The Clinical Characteristics of Anisakis Allergy in Korea
复制标题
DOI：
10.3904/kjim.2009.24.2.160
复制
发表时间：
2009-06-01
影响因子：
2.4
通讯作者：
Park, Hae-Sim
中科院分区：
文献类型：
--
作者：
Choi, Sung-Jin;Lee, Jae-Chun;Park, Hae-Sim
异尖线虫幼虫被人类摄取后会引起异尖线虫病。虽然有几个小组报告了西班牙和日本人的胃肠道异尖过敏，但我们的报告是第一次总结韩国10例异尖过敏病例的临床特征。我们招募了10名韩国患者(6名男性和4名女性)，他们在食用生鱼或海鲜后出现严重的过敏症状。通过检测血清中单纯性异尖线虫特异性IgE来证实对异尖线虫的致敏作用。异尖线虫病最常见的表现是荨麻疹(100%)，其次是腹痛(30%)和过敏反应(30%)。所有出现这些症状的患者都表现出对单纯沙门氏菌的血清特异性IgE升高(0.45~100kU/L)。9名患者(90%)表现为特应性和血清总IgE水平升高。怀疑携带异尖线虫的鱼类有比目鱼(40%)、鳕鱼(40%)、鱿鱼(30%)、海螺(110%)和金枪鱼(10%)。单纯性异尖线虫应被认为是成人患者在食用生鱼或海鲜后表现为荨麻疹、血管水肿和过敏反应的一种可能的食物过敏原。(《韩国实习医生》2009；24：160-163)
Anisakidae larvae can cause anisakiasis when ingested by humans. Although several groups have reported a gastrointestinal Anisakis allergy among people in Spain and Japan, our report is the first to summarize the clinical features of 10 Anisakis allergy cases in Korea. We enrolled 10 Korean patients (6 men and 4 women) who complained of aggravated allergic symptoms after ingesting raw fish or seafood. Sensitization to Anisakis was confirmed by detecting serum specific IgE to Anisakis simplex. The most common manifestation of anisakiasis was urticaria (100%), followed by abdominal pain (30%) and anaphylaxis (30%). All patients presenting with these symptoms also exhibited high serum specific IgE (0.45 to 100 kU/L) to A. simplex. Nine patients (90%) exhibited atopy and increased total serum IgE levels. The fish species suspected of carrying the Anisakis parasite were flatfish (40%), Congers (40%), squid (30%), whelk (110%), and tuna (10%). Anisakis simplex should be considered as a possible causative food allergen in adult patients presenting with urticaria, angioedema, and anaphylaxis following the consumption of raw fish or seafood. (Korean J Intern Med 2009;24:160-163)