Arginine Metabolism in Asthma
Arginine Metabolism in Asthma
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DOI：
10.1016/j.iac.2014.07.007
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发表时间：
2014-11-01
影响因子：
2.6
通讯作者：
Grasemann, Hartmut
中科院分区：
文献类型：
--
作者：
Scott, Jeremy A.;Grasemann, Hartmut
一氧化氮（NO）在调节气道张力和气道反应性中起重要作用。L-精氨酸代谢的改变导致NO脱氢酶底物L-精氨酸的可用性降低，以及NO合酶抑制剂如不对称二甲基精氨酸的存在，导致NO形成减少和哮喘气道功能障碍。旨在调节受损的L-精氨酸代谢的治疗干预可能有助于纠正哮喘中增强的气道张力和反应性。
Nitric oxide (NO) is important in the regulation of airway tone and airway responsiveness. Alterations in the L-arginine metabolism resulting in reduced availability of the substrate L-arginine for NO synthases, as well as the presence of NO synthase inhibitors such as asymmetric dimethylarginine, contribute to the reduced NO formation and airway dysfunction in asthma. Therapeutic interventions aiming to modulate the impaired L-arginine metabolism may help correct the enhanced airway tone and responsiveness in asthma.