Xenobiotic metabolism, oxidant stress and chronic pancreatitis - Focus on glutathione
Xenobiotic metabolism, oxidant stress and chronic pancreatitis - Focus on glutathione
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DOI：
10.1159/000051439
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发表时间：
1998-01-01
期刊：
影响因子：
3.2
通讯作者：
Wallig, MA
中科院分区：
文献类型：
--
作者：
Wallig, MA
慢性胰腺炎虽然在西方世界相对罕见，但在某些热带地区很常见，这些地区的主要作物如木薯富含氰苷。然后检验了这样的假设：慢性胰腺炎代表胰腺细胞色素P450单加氧酶和II相结合酶之间不协调的解毒反应的表现，导致腺泡细胞中谷胱甘肽的不可逆消耗。结论是，由于“外源性应激”，胰腺谷胱甘肽状态被破坏在慢性胰腺炎的演变过程中所起的核心作用怎么估计都不为过。这种情况与急性胰腺炎形成鲜明对比，在急性胰腺炎中，谷胱甘肽耗竭也起着关键作用，但其发生是由于活性氧的“应激”所致。
Chronic pancreatitis, although relatively rare in the Western World, is common in certain tropical zones where staple crops such as cassava are rich in cyanogenic glycosides, This paper reviews the evidence for a cyanide connection, with reference to experimental studies using another plant nitrile, crambene; and then examines the hypothesis that chronic pancreatitis represents a manifestation of uncoordinated detoxification reactions between pancreatic cytochrome P450 mono-oxygenases and phase II conjugating enzymes, resulting in the irreversible consumption of glutathione in the acinar cell. The conclusion is that the central role of disrupted pancreatic glutathione status, as a result of 'xenobiotic stress', in the evolution of chronic pancreatitis cannot be overestimated. This position contrasts with that in acute pancreatitis, in which glutathione depletion has a pivotal role too, but occurs as a result of 'stress' from reactive oxygen species.