PARTIAL DUPLICATION IN HINGE REGION OF IGA1 MYELOMA PROTEINS
PARTIAL DUPLICATION IN HINGE REGION OF IGA1 MYELOMA PROTEINS
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DOI：
10.1073/pnas.69.12.3673
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发表时间：
1972-01-01
影响因子：
11.1
通讯作者：
WOLFENST.C
中科院分区：
文献类型：
--
作者：
FRANGION.B;WOLFENST.C
发现两种人IgA 1骨髓瘤蛋白的“铰链”区的氨基酸序列是相同的。一个30个残基的片段含有3个半胱氨酸、12个脯氨酸和碳水化合物，并且铰链区的一小段序列至少重复两次。由于在IgA 2骨髓瘤蛋白的同一区域发现了12-13个残基的缺失，因此IgA 1分子可能是免疫球蛋白基因中插入部分重复基因片段的结果。
The aminoacid sequence of the “hinge” region of two human IgA1myeloma proteins was found to be identical. A 30-residue fragment contains 3 cysteines, 12 prolines, and carbohydrate, and the sequence of a small segment of the hinge region is repeated at least twice. Since a deletion of 12-13 residues was found in the same region of an IgA2myeloma protein, it is possible that IgA1molecules are the result of the insertion of a partially duplicated gene segment in the immunoglobulin genes.