Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse
Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse
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DOI：
10.1016/j.pain.2005.02.010
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发表时间：
2005-05-01
期刊：
影响因子：
7.4
通讯作者：
Stucky, CL
中科院分区：
文献类型：
--
作者：
Breese, NM;George, AC;Stucky, CL
C-纤维伤害感受器可基于生长因子依赖性和同工凝集素134（1134）结合分为两组。已经提出IB 4阴性伤害感受器有助于炎性疼痛。由于TRPV 1受体对炎性热痛觉过敏至关重要，我们假设炎症会使IB 4阴性而不是IB 4阳性的小直径神经元对TRPV 1刺激敏感。在完全弗氏佐剂（CFA）诱导小鼠后爪炎症后两天，分离腰4/5神经节，并将小直径（
C-fiber nociceptors can be divided into two groups based on growth factor dependency and isolectin 134 (1134) binding. IB4-negative nociceptors have been proposed to contribute to inflammatory pain. Since the TRPV1 receptor is critical for inflammatory heat hyperalgesia, we hypothesized that inflammation would sensitize IB4 negative but not IB4-positive small-diameter neurons to TRPV1 Stimuli. Two days after complete Freund's adjuvant (CFA)-induced inflammation in the hind paw of mice, lumbar 4/5 ganglia were dissociated and small-diameter (