3-hydroxyanthranilic acid is independently associated with monocyte chemoattractant protein-1 (CCL2) and macrophage inflammatory protein-1β (CCL4) in patients with chronic kidney disease
3-hydroxyanthranilic acid is independently associated with monocyte chemoattractant protein-1 (CCL2) and macrophage inflammatory protein-1β (CCL4) in patients with chronic kidney disease
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DOI：
10.1016/j.clinbiochem.2010.06.008
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发表时间：
2010-09-01
影响因子：
2.8
通讯作者：
Pawlak, Dariusz
中科院分区：
文献类型：
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作者：
Pawlak, Krystyna;Kowalewska, Anna;Pawlak, Dariusz
目的：CC-趋化因子和犬尿氨酸途径（KP）代谢物与慢性肾病（CKD）患者中加速的动脉粥样硬化相关。我们评估了血浆邻氨基苯甲酸（AA）、3-羟基邻氨基苯甲酸（3-HAA）水平及其与CC-趋化因子的可能关系，Cu/Zn超氧化物歧化酶（Cu/Zn SOD）作为氧化状态和高敏C反应蛋白（hsCRP）的标志物结果：与对照组相比，CKD患者血浆CCL 2、CCL 4、AA、3-HAA、Cu/Zn SOD和hsCRP水平均显著升高。多元逐步回归分析显示，炎症、肾功能和3-HAA水平与CCL 2升高显著相关，而年龄、3-HAA和肾功能与CCL 4升高显著相关。结论：CC-趋化因子系统与KP活化相关，可能是CKD人群动脉粥样硬化加速的机制之一。(C)2010年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objectives: CC-chemokines and kynurenine pathway (KP) metabolites are associated with accelerated atherosclerosis in chronic kidney disease (CKD) patients.Design and methods: We evaluate the plasma levels of anthranilic acid (AA), 3-hydroxyanthranilic acid (3-HAA) and their possible relationship with CC-chemokines, Cu/Zn superoxide dismutase (Cu/Zn SOD) as the marker of oxidative status and high sensitivity C-reactive protein (hsCRP) as an index of inflammation in the population of 48 CKD patients.Results: Compared with controls, CKD patients showed a significant increase in plasma concentrations of CCL2, CCL4, AA, 3-HAA, Cu/Zn SOD and hsCRP. Multiple stepwise regression analysis identified inflammation, renal function and 3-HAA levels as the independent variables significantly associated with increased CCL2; whereas age, 3-HAA and renal function as independent variables associated with CCL4.Conclusions: These results suggest a relationship between CC-chemokine system and KP activation, which may represent one of the mechanisms involved in the accelerated atherosclerosis in CKD population. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.