Cartilaginous End Plates: Quantitative MR Imaging with Very Short Echo Times-Orientation Dependence and Correlation with Biochemical Composition
Cartilaginous End Plates: Quantitative MR Imaging with Very Short Echo Times-Orientation Dependence and Correlation with Biochemical Composition
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DOI：
10.1148/radiol.14141082
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发表时间：
2015-02-01
期刊：
影响因子：
19.7
通讯作者：
Lotz, Jeffrey C.
中科院分区：
文献类型：
--
作者：
Fields, Aaron J.;Han, Misung;Lotz, Jeffrey C.
目的：测量T2* 的人软骨终板通过使用磁共振（MR）成像与非常短的回波时间，并确定T2* 和T2* 和生化constituency.Materials和方法之间的关系终板的方向的影响：这项研究是从机构审查委员会批准豁免，并不需要知情同意。制备了34个含有软骨终板和软骨下骨的3具尸体腰椎样本（来自年龄分别为51岁、57岁和66岁的受试者）。通过使用三维极短回波时间序列（重复时间毫秒/回波时间毫秒，30/0.075，2，5，12，18），使用3-T成像仪对样本进行T2* 定量成像。使用端板在相对于恒定磁感应场的三个方向上对样品进行成像：0度、54.7度和90度。成像后，分析软骨的水、糖胺聚糖和胶原蛋白含量。Pearson相关系数用于研究方位对T2* 和生化组成之间关系的影响。当在54.7度方向测量时，T2* 显著更长（21.8毫秒+/- 2.8 [+/-平均值的标准误差]）比0度（10.0毫秒+/- 0.7，P <0.001）或90度（9.9毫秒+/- 0.4，P <0.001）。在54.7度，T2* 与糖胺聚糖含量高度相关（r = 0.85，P <0.001），胶原与糖胺聚糖的比例（r = 20.79，P < .001），含水量（r = 0.62，P = .02）;在0 °和90 °时，这些关系没有显著差异，最小P值为.19。结论：T2* 评估可以无创估计软骨终板的退化;然而，基于T2* 的生化成分估计的准确性取决于终板的方向。(C)RSNA，2014年
Purpose: To measure the T2* of the human cartilaginous end plate by using magnetic resonance (MR) imaging with very short echo times and to determine the effect of the orientation of the end plate on T2* and on relationships between T2* and biochemical composition.Materials and Methods: This study was exempt from institutional review board approval, and informed consent was not required. Thirty-four samples of three cadaveric lumbar spines (from subjects who died at ages 51, 57, and 66 years) containing cartilaginous end plates and subchondral bone were prepared. Samples were imaged with a 3-T imager for T2* quantification by using a three-dimensional very short echo time sequence (repetition time msec/echo times msec, 30/0.075, 2, 5, 12, 18). Samples were imaged with the end plate at three orientations with respect to the constant magnetic induction field: 0 degrees, 54.7 degrees, and 90 degrees. After imaging, the cartilage was assayed for its water, glycosaminoglycan, and collagen content. Pearson correlations were used to investigate the effect of orientation on the relationships between T2* and biochemical composition.Results: T2* was significantly longer when measured at an orientation of 54.7 degrees (21.8 msec +/- 2.8 [+/- standard error of the mean]) than at 0 degrees (10.0 msec +/- 0.7, P < .001) or 90 degrees (9.9 msec +/- 0.4, P < .001). At 54.7 degrees, T2* was highly correlated with glycosaminoglycan content (r = 0.85, P < .001), the collagen-to-glycosaminoglycan ratio (r = 20.79, P < .001), and water content (r = 0.62, P = .02); at 0 degrees and 90 degrees, there were no significant differences in these relationships, with a minimum P value of .19.Conclusion: T2* evaluation can allow noninvasive estimation of the degeneration of the cartilaginous end plate; however, the accuracy of T2*-based estimates of biochemical composition depends on the orientation of the end plate. (C) RSNA, 2014