Micronutrients and ovarian cancer: A case-control study in Italy
Micronutrients and ovarian cancer: A case-control study in Italy
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DOI：
10.1023/a:1013124112542
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发表时间：
2001-01-01
影响因子：
50.5
通讯作者：
Franceschi, S
中科院分区：
文献类型：
--
作者：
Bidoli, E;La Vecchia, C;Franceschi, S
背景资料：选定的微量营养素，维生素和矿物质在上皮性卵巢癌的病因学的作用进行了调查，使用的数据从1992年和1999年之间进行的病例对照研究在5 Italian areas.Patients和方法：病例1031例经组织学证实的事件上皮性卵巢癌。对照组为2411例因急性非肿瘤性疾病入住同一集水区主要医院的受试者。饮食习惯，引起使用验证的食物频率问卷，包括78个食物组和食谱。比值比（OR）和95%置信区间（95%CI）由营养素摄入量的五分位数计算。（OR = 0.6; 95% CI：0.5-0.8），β-胡萝卜素（OR = 0.8; 95% CI：0.6-1.0），叶黄素/玉米黄质（OR = 0.6; 95% CI：0.5-0.8，最高与最低五分位摄入量）和钙摄入量（OR = 0.7; 95% CI：0.6-1.0）。当考虑钙和维生素E的联合作用时，两种微量营养素摄入量最高的受试者与摄入量最低的受试者相比，OR达到0.4（95%CI：0.3-0.7）。结果是一致的跨层的绝经状态，奇偶校验和家族史的卵巢癌或乳腺cancer.Conclusions：摄入选定的微量营养素，这是正相关的饮食中富含蔬菜和水果，呈负相关卵巢癌。
Background: The role of selected micronutrients, vitamins and minerals in the aetiology of epithelial ovarian cancer was investigated using data from a case-control study conducted between 1992 and 1999 in five Italian areas.Patients and methods:Cases were 1031 patients with histologically confirmed incident epithelial ovarian cancer. Controls were 2411 subjects admitted for acute, non-neoplastic diseases to major hospitals in the same catchment areas. Dietary habits were elicited using a validated food frequency questionnaire including 78 food groups and recipes. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed by quintiles of intake of nutrients.Results: Inverse associations emerged for vitamin E (OR = 0.6; 95% CI: 0.5-0.8), beta-carotene (OR = 0.8; 95% CI: 0.6-1.0), lutein/zeaxanthin (OR = 0.6; 95% CI: 0.5-0.8 for the highest vs. the lowest quintile of intake), and calcium intake (OR = 0.7; 95% CI: 0.6-1.0). When the combined effect of calcium and vitamin E was considered, the OR reached 0.4 (95% CI: 0.3-0.7) for subjects in the highest compared to those in the lowest intake tertile of both micronutrients. Results were consistent across strata of menopausal status, parity and family history of ovarian or breast cancer.Conclusions: The intake of selected micronutrients, which were positively correlated to a diet rich in vegetables and fruits, was inversely associated with ovarian cancer.