SUBTHRESHOLD EXCITATORY ACTIVITY AND MOTONEURON DISCHARGE DURING REM PERIODS OF ACTIVE SLEEP
SUBTHRESHOLD EXCITATORY ACTIVITY AND MOTONEURON DISCHARGE DURING REM PERIODS OF ACTIVE SLEEP
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DOI：
10.1126/science.6310749
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
MORALES, FR
中科院分区：
文献类型：
--
作者：
CHASE, MH;MORALES, FR
活跃睡眠的快速眼动期的一个显着悖论是肌肉抽搐和抽搐的发生，其典型特征是躯体运动肌无力加剧。检查了导致这些肌阵挛活动模式的特定运动神经元膜电位过程。在准备长期研究的猫的腰椎运动神经元中进行细胞内检查，这些过程包括反复出现的去极化膜电位变化和全尺寸或部分幅度的自发动作电位。逆向诱导的尖峰侵入体细胞常常被阻止。超极化电位在自发尖峰之间的间隔中很明显。在去极化和尖峰活动之前立即观察到超极化，与清醒期间总是发生的运动神经元膜电位的逐渐去极化相反。在快速眼球运动期间，结合肌肉抽搐和抽搐，强烈的兴奋性输入叠加在抑制性输入的背景上。因此，出现的膜电位变化的独特模式似乎是兴奋性和抑制性过程同时共同激活的结果。
A striking paradox of the rapid eye movement periods of active sleep, which are typically characterized by the exacerbation of somatomotor atonia, is the occurrence of muscle twitches and jerks. The specific motoneuron membrane potential processes responsible for these myoclonic patterns of activity were examined. In lumbar motoneurons, examined intracellularly in the cat prepared for long-term study, these processes consisted of recurrent depolarizing membrane potential shifts and spontaneous action potentials that were either full-sized or of partial amplitude. The invasion of antidromically induced spikes into the soma was often blocked. Hyperpolarizing potentials were evident in the intervals between spontaneous spikes. Hyperpolarization was also observed immediately before depolarization and spike activity, in contrast to the gradual depolarization of the motoneuron membrane potential that always occurred during wakefulness. During rapid eye movement periods, in conjunction with muscle twitches and jerks, a strong excitatory input is superimposed on a background of inhibitory input. The unique patterns of membrane potential change that arise thus seem to result from the simultaneous coactivation of excitatory and inhibitory processes.