COPPER,ZINC-SUPEROXIDE DISMUTASE AND HYDROGEN-PEROXIDE - A HYDROXYL RADICAL GENERATING-SYSTEM
COPPER,ZINC-SUPEROXIDE DISMUTASE AND HYDROGEN-PEROXIDE - A HYDROXYL RADICAL GENERATING-SYSTEM
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DOI：
10.1016/0009-8981(94)90088-4
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发表时间：
1994-10-14
影响因子：
5
通讯作者：
MARX, JJM
中科院分区：
文献类型：
--
作者：
KONINGSBERGER, JC;VANASBECK, BS;MARX, JJM
Because superoxide (O-2(radical-anion)) is a mediator of inflammation, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) has been employed as an anti-inflammatory compound. However, Cu,Zn-SOD can increase intra- and extracellular H2O2. This may react with the Cu atom of SOD in a Fenton-type reaction producing the hydroxyl radical((OH)-O-.). With a non-physiological concentration of H2O2 (0.8 mmol/l) to stimulate chemiluminescence (CL) at a level
