Cutaneous blastic plasmacytoid dendritic cell neoplasm occurring after spontaneous remission of acute myeloid leukemia: a case report and review of literature
Cutaneous blastic plasmacytoid dendritic cell neoplasm occurring after spontaneous remission of acute myeloid leukemia: a case report and review of literature
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急性髓性白血病自发缓解后发生皮肤母细胞性浆细胞样树突状细胞肿瘤一例报告并文献复习
DOI：
10.1007/s12032-012-0215-y
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发表时间：
2012-12-01
期刊：
影响因子：
3.4
通讯作者：
Huang, He
中科院分区：
文献类型：
--
作者：
Xie, Wanzhuo;Zhao, Yanmin;Huang, He
急性髓系白血病（AML）的自发缓解是一种极其罕见的事件。病因与感染、输血或粒细胞集落刺激因子治疗有关，这些治疗会触发免疫反应发挥抗白血病作用。缓解通常是暂时的，随后会迅速复发。然而，我们介绍了一名 42 岁男性 AML-M5a 自发缓解的病例，他没有复发，但发展为一种罕见的侵袭性淋巴瘤，称为皮肤母细胞性浆细胞样树突状细胞肿瘤 (BPDCN)。肿瘤细胞 CD4、CD56、CD43、CD45 和 CD123 呈阳性，但其他谱系特异性标记呈阴性。据我们所知，这是 AML 自发缓解后发生 BPDCN 的第一份报告，尽管已经观察到一些 BPDCN 可能转变为粒细胞白血病。这两种疾病的发生绝非巧合。此类病例的发现可能进一步揭示 BPDCN 与骨髓疾病之间的内在联系。
Spontaneous remission of acute myeloid leukemia (AML) is an extremely uncommon event. The etiology is associated with infection, blood transfusion or granulocyte colony-stimulating factor therapy, which trigger immune responses to exert an antileukemic effect. The remission is usually temporary and followed by rapid relapse. However, we present a case of a 42-year-old man with spontaneous remission of AML-M5a, who did not relapse but developed a rare and aggressive lymphoma, named cutaneous blastic plasmacytoid dendritic cell neoplasm (BPDCN). The neoplasm cells are positive for CD4, CD56, CD43, CD45, and CD123, but negative for other lineage-specific markers. To our knowledge, this is the first report of BPDCN occurring after spontaneous remission of AML, although it has been observed that some BPDCN could shift to myeloid leukemia. Occurrence of the two diseases is more than a coincidence. Discovery of such cases may shed further light on the inner connection between BPDCN and myeloid disorders.