Visual working memory deficits in patients with Parkinson's disease are due to both reduced storage capacity and impaired ability to filter out irrelevant information
Visual working memory deficits in patients with Parkinson's disease are due to both reduced storage capacity and impaired ability to filter out irrelevant information
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DOI：
10.1093/brain/awq197
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发表时间：
2010-09-01
期刊：
影响因子：
14.5
通讯作者：
Hackley, Steven A.
中科院分区：
文献类型：
--
作者：
Lee, Eun-Young;Cowan, Nelson;Hackley, Steven A.
鉴于帕金森病广泛影响额纹状体回路，这种疾病与工作记忆的减少有关也就不足为奇了。我们测试了这种减少是否是由于存储容量减少或排除任务无关项目的能力受损。21名停药患者和28名年龄匹配的对照受试者进行了视觉空间记忆任务，同时记录了他们的脑电图。这项任务要求他们记住红色矩形在屏幕上的方向，而忽略所有的绿色矩形。行为和脑电图测量表明，帕金森病患者在过滤干扰物方面受损，并且他们能够在记忆中记住的项目比对照组少。研究结果支持了最近的建议，即基底神经节有助于控制工作记忆的访问。
Given that Parkinson's disease broadly affects frontostriatal circuitry, it is not surprising that the disorder is associated with a reduction of working memory. We tested whether this reduction is due to diminished storage capacity or impaired ability to exclude task-irrelevant items. Twenty-one medication-withdrawn patients and 28 age-matched control subjects performed a visuospatial memory task while their electroencephalograms were recorded. The task required them to remember the orientations of red rectangles within the half of the screen that was cued while ignoring all green rectangles. Behavioural and electroencephalogram measures indicated that patients with Parkinson's disease were impaired at filtering out distracters, and that they were able to hold fewer items in memory than control subjects. The results support recent suggestions that the basal ganglia help control access to working memory.